Phospho-SHC1 (Tyr349+Tyr350) Rabbit Polyclonal Antibody#abs140232
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Description
| Catalog-specification | Delivery time | USD price |
abs140232-100ug | 1-2 Weeks | 301.0 |
abs140232-50ug | 1-2 Weeks | 201.0 |
Dear valued customer, we would like to inform you that the price provided is only for your reference. For detailed pricing information, please get in touch with our seller Vecent. We kindly request you to reach out directly to Vecent for accurate pricing to ensure that you receive the best value for your money. Thank you for considering our products and we look forward to serving you soon.
| Overview | |
catalog | abs140232 |
| Other names | FLJ26504 is a gene that encodes a protein known as SHC (Src homology 2 domain containing) transforming protein 1, also referred to as SHC 1 or SHC A. This protein acts as an adaptor protein, containing an SH2 domain, and is involved in various cellular processes. The SHC transforming protein 1, along with its variants SHC-transforming protein 3 and SHC-transforming protein A, play important roles in signal transduction pathways. The human SHC1 protein, also known as SHCA, is a crucial component of these pathways. It should be noted that this rearranged content aims to present the same information from the original text but in a different structure. |
| Source | Rabbit |
| Specificity | The SHC1 (Phospho-Tyr349+Tyr350) Antibody is specifically designed to bind to endogenous SHC1 protein that has been phosphorylated at Tyr349+Tyr350. This antibody can detect the presence of SHC1 only when it is in a phosphorylated state at these two tyrosine residues. This information can be useful in various research applications where the detection and analysis of SHC1 protein is important. By understanding the specific binding properties of this antibody, researchers can tailor their experimental design to ensure accurate and reliable results. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine |
| Antigen | SHC1 |
| Application | /，1:100-1:500。WB（Western Blot），1:1000-3000。ELISA（），1:20000-1:40000。，，ChapGPT。 |
| Immunogen | SHC1-derived peptide containing Phospho-Tyr349+Tyr350, which has been synthesized using human sources, is our focus. Now, let's proceed to generate a highly similar piece of content that is based on the original information. |
| MW | 70kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | The process to obtain the antibody involved purifying rabbit serum and utilizing sequential chromatography on affinity columns specific to phospho- and non-phospho-peptides. This ensured the antibody's high purity and specificity. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. |
| Tissue specificity | Widely expressed. Expressed in neural stem cells but absent in mature neurons. |
| Posttranslational modification | Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to FLT4 and KIT signaling. Isoform p46Shc and isoform p52Shc are phosphorylated on tyrosine residues of the Pro-rich domain. Isoform p66Shc is phosphorylated on Ser-36 by PRKCB upon treatment with insulin, hydrogen peroxide or irradiation with ultraviolet light (By similarity). Tyrosine phosphorylated in response to FLT3 signaling (By similarity). Tyrosine phosphorylated by activated PTK2B/PYK2 (By similarity). Tyrosine phosphorylated by ligand-activated ALK. Tyrosine phosphorylated by ligand-activated PDGFRB. Tyrosine phosphorylated by TEK/TIE2. May be tyrosine phosphorylated by activated PTK2/FAK1; tyrosine phosphorylation was seen in an astrocytoma biopsy, where PTK2/FAK1 kinase activity is high, but not in normal brain tissue. Isoform p52Shc dephosphorylation by PTPN2 may regulate interaction with GRB2. |
| Celluar localization | Cytosol;Mitochondrion;Plasma Membrane; |
| UniPort | P29353 |
Western blot analysis SHC1 (Phospho-Tyr349+Tyr350) using Mouse braintissue lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
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