Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Phospho-PPARA (Ser12) Rabbit Polyclonal Antibody#abs140221

Please note that the price mentioned above is for reference purposes only. Kindly get in touch with our seller, Vecent, for more detailed pricing information. Western blot analysis PPARA (Phospho-Ser12) using UV treated COS7 whole cell lysates This product is for research use only, not for use...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs140221-100ug	1-2 Weeks	301.0
abs140221-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is for reference purposes only. Kindly get in touch with our seller, Vecent, for more detailed pricing information.

Overview
catalog	abs140221
Other names	Peroxisome proliferator-activated receptor alpha, also known as PPAR-alpha, is a nuclear receptor subfamily 1 group C member 1 that plays a critical role in lipid metabolism and inflammation. It is encoded by the MGC2237 and MGC2452 genes and is also referred to as NR1C1. OTTHUMP00000197740 and OTTHUMP00000197741 are additional identifiers for this protein. PPAR-alpha is a key transcriptional regulator that controls the expression of genes involved in fatty acid oxidation, lipoprotein metabolism, and glucose homeostasis. It is primarily expressed in tissues with high metabolic rates, such as the liver, heart, and skeletal muscle. Targeting PPAR-alpha has emerged as a promising strategy for the treatment of metabolic disorders, including hyperlipidemia, insulin resistance, and non-alcoholic fatty liver disease. Several drugs, such as fibrates and thiazolidinediones, have been developed that activate PPAR-alpha and improve metabolic function. In conclusion, PPAR-alpha is a crucial player in lipid metabolism and energy homeostasis. Its dysregulation is linked to various metabolic disorders, and targeting PPAR-alpha has therapeutic potential for these conditions.
Source	Rabbit
Specificity	The PPARA (Phospho-Ser12) Antibody is designed to specifically recognize and detect the natural levels of PPARA protein, but only when it undergoes phosphorylation at Serine 12. This antibody provides a valuable tool for researchers to study the phosphorylation status and activity of PPARA in various biological contexts. By specifically targeting the phosphorylated form of PPARA at Serine 12, this antibody enables researchers to investigate the functional implications of this specific post-translational modification.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Sheep;Bovine;Dog;Horse;
Antigen	PPARA
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	The peptide derived from human PPARA (Phospho-Ser12) has been synthesized and is composed of rearranged amino acid sequences. The generated content is highly similar to the original text information, while being presented in a distinct manner.
MW	52 kDa
Properties
Concentration	1mg/ml
purification	，。，。
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to keep the product at a temperature of -20 °C for a period of one year. It is advisable to prevent the product from undergoing multiple freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Tissue specificity	Skeletal muscle, liver, heart and kidney.
Celluar localization	Nucleus;
UniPort	Q07869