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Phospho-NACA (Ser43) Rabbit Polyclonal Antibody#abs140119

Description

Catalog-specification	Delivery time	USD price
abs140119-100ug	1-2 Weeks	301.0
abs140119-50ug	1-2 Weeks	201.0

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Overview
catalog	abs140119
Other names	The Nascent polypeptide associated complex alpha subunit, also known as Alpha NAC or NAC-alpha, is a protein that plays an essential role in protein synthesis. It is encoded by the HSD48 gene and is also referred to as Hom s 2.02, MGC117224, NACA, NACA/1.9.2, NACA_HUMAN, and NACA1. The Nascent polypeptide associated complex subunit alpha is responsible for binding to newly synthesized polypeptides as they emerge from the ribosomes during protein synthesis. Alpha NAC facilitates the proper folding and assembly of these polypeptides, ensuring their stability and functionality. Deficiencies in Alpha NAC have been associated with numerous diseases and disorders, including neurodegenerative diseases, cancer, and developmental disorders. As such, understanding the role of this essential protein could have significant implications for the prevention and treatment of these conditions. Overall, the Nascent polypeptide associated complex alpha subunit is a vital component of the cellular machinery responsible for protein synthesis. By ensuring the proper folding and assembly of newly synthesized polypeptides, Alpha NAC helps to maintain protein homeostasis and promote cellular health.
Source	Rabbit
Specificity	The NACA (Phospho-Ser43) Antibody is capable of detecting the presence of phosphorylated Ser43 in endogenous levels of NACA. However, it does not detect non-phosphorylated NACA. This particular antibody is important for studies that aim to investigate the role of Ser43 phosphorylation in the modulation of NACA function. Its specificity is due to the high affinity it has for the phosphorylated form of NACA at Ser43. Overall, the antibody is a valuable tool for researchers interested in studying NACA phosphorylation-related pathways.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Sheep;Bovine
Antigen	NACA
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	One possible rearrangement could be: A phosphorylated peptide of serine 43 in human NACA has been synthesized. This peptide is highly similar to the original sequence found in the human body and was created using information from the original NACA protein.
MW	24KD
Properties
Concentration	1mg/ml
purification	The purification of the antibody was carried out using a phospho- and non-phospho-peptide affinity column approach to sequentially purify the rabbit serum. This resulted in purified rabbit serum antibody, which is highly specific and selective for the targeted antigen. The affinity purification process ensured that the antibody is of high quality and will reliably bind to the designated target. Overall, this approach yielded a highly effective and purified antibody that is suitable for a variety of research applications.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity of your product, it should be stored at a temperature of -20°C for up to one year. It is important to note that exposing the product to repeated freeze/thaw cycles can have negative effects on its overall quality. Thus, it is recommended to avoid such cycles in order to maintain the integrity of your product.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.
Tissue specificity	Ubiquitously expressed.
Posttranslational modification	Phosphorylation of Thr-159 by GSK3B may promote proteasome mediated degradation (By similarity). Phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization.
Celluar localization	Extracellular region or secreted;Nucleus;
UniPort	Q13765