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Phospho-MNK2 (Thr24) Rabbit Polyclonal Antibody#abs139999

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Description

Catalog-specification	Delivery time	USD price
abs139999-100ug	1-2 Weeks	301.0
abs139999-50ug	1-2 Weeks	201.0

Overview
catalog	abs139999
Other names	G protein-coupled receptor kinase 7, also known as GPRK7 or MAP kinase-interacting serine/threonine kinase 2 (MKNK2), is a protein kinase that interacts with mitogen-activated protein kinases (MAPKs) to integrate signals in cellular pathways. It is also referred to as MAP kinase signal-integrating kinase 2 or MAPK interacting kinase 2. The function of GPRK7/MKNK2 is to regulate the activity of MAPKs by phosphorylating them, thereby modulating downstream signaling events. This protein kinase plays a crucial role in various cellular processes, including cell growth, differentiation, and apoptosis. Its involvement in MAPK signaling pathways highlights its significance in regulating important physiological and pathological processes. Research on GPRK7/MKNK2 continues to shed light on its precise mechanisms of action and potential therapeutic applications.
Source	Rabbit
Specificity	The MNK2 (Phospho-Thr249) Antibody is capable of identifying MNK2 at its endogenous levels, but only when it is phosphorylated at Thr249.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Chicken;Pig;Dog;Sheep;Bovine;
Antigen	MNK2
Application	，：WB1:1000-3000，IHC1:50-1:200，ELISA（）1:20000-1:40000。
Immunogen	An artificial peptide fragment was created using the sequence of human MNK2 (Phospho-Thr249). To generate a comparable text, the content should be rephrased while staying true to the original information.
MW	52 kDa
Properties
Concentration	1mg/ml
purification	This purified antibody was derived from rabbit serum and obtained through affinity purification. The purification process involved sequential chromatography on both phospho- and non-phospho-peptide affinity columns. By using this method, the antibodies were specifically targeted and separated based on their affinity for the specific peptide columns.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As2O3-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.
Tissue specificity	Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1.
Posttranslational modification	Dual phosphorylation of Thr-244 and Thr-249 activates the kinase. Phosphorylation of Thr-379 activates the kinase. Phosphorylated upon arsenic trioxide As2O3 treatment. Phosphorylated by MAPK1/ERK2, MAPK11 and MAPK14. Dephosphorylated by PP2A.
Celluar localization	Nucleus;
UniPort	Q9HBH9