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Phospho-MKP-1 (Ser323) Rabbit Polyclonal Antibody#abs140114

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Description

Catalog-specification	Delivery time	USD price
abs140114-100ug	1-2 Weeks	301.0
abs140114-50ug	1-2 Weeks	201.0

Overview
catalog	abs140114
Other names	Mitogen-activated protein kinase phosphatase 1, also known as Dual Specificity Phosphatase 1 or Dual Specificity Protein Phosphatase 1, is a protein encoded by the DUSP1 gene in humans. It is also referred to as DUS1_HUMAN or DUSP 1. Other names for this protein include Dual Specificity Protein Phosphatase hVH1, HVH1, MAP Kinase Phosphatase 1, MKP-1, MKP1, Protein Tyrosine Phosphatase CL100, Protein-Tyrosine Phosphatase CL100, PTPN10, Serine/Threonine Specific Protein Phosphatase, and VH1. This protein plays a crucial role in regulating cellular signaling pathways by dephosphorylating both tyrosine and serine/threonine residues in target proteins. Its diverse range of functions also includes modulating the activity of mitogen-activated protein kinases (MAPKs), which are key regulators of various cellular processes. Overall, Dual Specificity Phosphatase 1 acts as an important regulator of intracellular signaling and contributes to the maintenance of cellular homeostasis.
Source	Rabbit
Specificity	The antibody for MKP-1 (Phospho-Ser323) is specifically designed to detect only the phosphorylated form of MKP-1 at Ser323. This means that the antibody can accurately identify endogenous levels of MKP-1 that have undergone this specific type of phosphorylation.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Pig;Dog;Horse;Bovine
Antigen	MKP-1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A peptide has been synthesized which is derived from human MKP-1 and specifically targets Phospho-Ser323. The peptide has been designed to closely resemble the original sequence and function of MKP-1, with the goal of studying the potential therapeutic properties of this molecule. By incorporating the unique phosphorylation site into the peptide, it is hoped that the resulting compound will effectively regulate the activity of cellular signaling pathways. Further studies will be necessary to fully understand the potential benefits and limitations of this synthesized peptide.
MW	39 kDa
Properties
Concentration	1mg/ml
purification	A sequential chromatography technique was used to purify the antibody from rabbit serum. The purification process involved affinity purification using both phospho- and non-phospho-peptide affinity columns. This method ensured the isolation of highly specific antibodies.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality, keep it stored for a year at -20 °C. Make sure to prevent the product from undergoing multiple freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Tissue specificity	Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.