Phospho-HP1-beta (Thr51) Rabbit Polyclonal Antibody#abs140312
Please note that the price listed is only for your reference. For more detailed pricing information, we suggest you get in touch with our seller Vecent. Western blot analysis HP1-β (Phospho-Thr51) using Insulin treated 293 whole cell lysates This product is for research use only, not for use in...
Description
| Catalog-specification | Delivery time | USD price |
abs140312-100ug | 1-2 Weeks | 301.0 |
abs140312-50ug | 1-2 Weeks | 201.0 |
Please note that the price listed is only for your reference. For more detailed pricing information, we suggest you get in touch with our seller Vecent.
| Overview | |
catalog | abs140312 |
| Other names | The CBX1 protein, also known as CBX or Cbx1, is a chromobox homolog 1 (HP1 beta homolog Drosophila) found in humans. It is also referred to as Chromobox protein homolog 1 or Drosophila HP1 beta. This protein, commonly known as HP1 beta, is involved in regulating heterochromatin structure and gene expression. HP1 beta, or heterochromatin protein p25 beta, plays a role in modulating gene activity and is encoded by the HP1Hsbeta gene. In Drosophila, it is known as the homolog of HP1. Additionally, this protein is also referred to as M31 or MOD1, which stands for Modifier 1 protein. The complete coding sequence (cds) of the human heterochromatin protein p25 mRNA is represented by CBX1. |
| Source | Rabbit |
| Specificity | If you need to detect the levels of HP1-β that are phosphorylated at Thr51, the HP1-β (Phospho-Thr51) Antibody is your ideal choice. This antibody specifically targets the endogenous HP1-β that is phosphorylated at Thr51, allowing for accurate and reliable detection. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine |
| Antigen | HP1-β |
| Application | WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000 |
| Immunogen | A peptide synthesized from human HP1-β (Phospho-Thr51) has been created through careful lab procedures. The peptide has been derived from the amino acid sequence of HP1-β and has been modified with a phosphorylation at threonine residue number 51. This modification can potentially alter the protein's function and interactions with other molecules in a biological system. Scientists are studying the synthesized peptide to better understand its properties and functions, which could lead to new therapeutic approaches for a range of diseases. |
| MW | 25 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | The process involved in obtaining the antibody is as follows: first, rabbit serum was purified, and then affinity purification was carried out using phospho- and non-phospho-peptide affinity columns through sequential chromatography. This method ensured that the antibody obtained was highly specific and targeted the desired antigens. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. |
| Tissue specificity | Expressed in all adult and embryonic tissues. |
| Posttranslational modification | Not phosphorylated.Ubiquitinated. |
| Celluar localization | Cytoskeleton;Nucleus; |
| UniPort | P83916 |
Western blot analysis HP1-β (Phospho-Thr51) using Insulin treated 293 whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
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