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Rabbit Anti-PDCD1LG2 Polyclonal Antibody#abs132940

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Description

Catalog-specification	Delivery time	USD price
abs132940-100ug	1-2 Weeks	301.0
abs132940-50ug	1-2 Weeks	201.0

Overview
catalog	abs132940
Description	Through its involvement in the costimulatory signal, this particular factor plays a crucial role in T-cell proliferation and the production of IFNG, independently of PDCD1. When interacting with PDCD1, it leads to the inhibition of T-cell proliferation by impeding cell cycle progression and the generation of cytokines.
Other names	Butyrophilin B7DC, also known as B7 dendritic cell molecule or B7-DC, is a molecule involved in immune regulation. It is encoded by the bA574F11.2 gene and is also known as CD273 or CD273 antigen. Other names for this molecule include MGC142238, MGC142240, PD-1 ligand 2, PD-L2, PDCD1 ligand 2, PDCD1L2, Pdcd1lg2, PDL2, and programmed cell death 1 ligand 2. Butyrophilin B7DC plays a crucial role in regulating the immune response by binding to its receptor, PD-1 (programmed cell death protein 1), on T cells and inhibiting their activation. This interaction helps prevent excessive immune responses and maintains immune homeostasis. Understanding the function of Butyrophilin B7DC and its interaction with PD-1 has significant implications for immunotherapy and the treatment of various diseases, including cancer. Manipulating this pathway may enable the development of novel therapeutic strategies to enhance or suppress the immune response, depending on the clinical context. In summary, Butyrophilin B7DC, also known as B7-DC or CD273, is an important molecule involved in immune regulation. Its interaction with PD-1 is critical for maintaining immune homeostasis and has implications for therapeutic interventions in various diseases.
Source	Rabbit
Specificity	The antibody for PDCD1LG2 is designed to recognize the complete endogenous level of the protein.
Species Reactivity	Human;Mouse
Antigen	PDCD1LG2
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	31 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography was employed to purify the antiserum, and this process involved the utilization of SulfoLink™ Coupling Resin. Please note that the provided content has been rearranged to maintain its similarity to the original information.
Clonality	Polyclonal Antibody
Stability & Storage	Make sure to store at -20 °C for a duration of one year and prevent any repeated freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).
Tissue specificity	Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	Q9BQ51