Phospho-EPHB1/2 (Tyr778/Tyr780) Rabbit Polyclonal Antibody#abs140259
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Description
| Catalog-specification | Delivery time | USD price |
abs140259-100ug | 1-2 Weeks | 301.0 |
abs140259-50ug | 1-2 Weeks | 201.0 |
Please note that the price provided is for reference purposes only. For detailed pricing information, kindly get in touch with our sales representative, Vecent. To generate a highly similar content, we recommend rearranging the original text as follows: "Kindly note that the price mentioned above is only intended for your reference. To obtain detailed pricing information, please contact our seller, Vecent."
| Overview | |
catalog | abs140259 |
| Other names | EPH receptor B1 is also known as Cek 6, EK6, ELK, Elkh, Eph tyrosine kinase 2, EPH-like kinase 6, Ephb1, Ephrin type B receptor 1, EPHT2, HEK 6, HEK6, NET, Neuronally-expressed EPH-related tyrosine kinase, soluble EPHB1 variant 1, Tyrosine protein kinase receptor EPH 2, Tyrosine-protein kinase receptor EPH-2, cek5, Developmentally regulated EPH related tyrosine kinase, DRT, EK5, ELK related protein tyrosine kinase. On the other hand, EPH receptor B2 is known as EPH tyrosine kinase 3, EPH-like kinase 5, EPHB2, Ephrin type B receptor 2, EPHT 3, ERK, ETECK, hEK5, Nuk, Prkm 5, Receptor protein tyrosine kinase HEK 5, Renal carcinoma antigen NY-REN-47, Sek 3, Tyro 5, Tyrosine protein kinase receptor CEK 5, Tyrosine protein kinase receptor EPH 3, Tyrosine protein kinase receptor QEK 5, Tyrosine-protein kinase receptor EPH-3, Tyrosine-protein kinase TYRO5. Please note that the generated content is a rearrangement of the original information provided above. |
| Source | Rabbit |
| Specificity | The antibody EPHB1/2 (Phospho-Tyr778/Tyr780) specifically recognizes EPHB1/2 protein when it is phosphorylated at the Tyr778/Tyr780 sites. This antibody is designed to detect endogenous levels of the phosphorylated form of EPHB1/2 protein. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine |
| Antigen | EPHB1/2 |
| Application | For Western blot analysis, a dilution factor of 1:1000-3000 is recommended. When performing immunofluorescence or immunocytochemistry, a dilution factor of 1:100-1:500 is the most appropriate. For ELISA assays using peptide as antigen, a dilution factor of 1:20000-1:40000 is recommended. It is important to adhere to these dilution guidelines for optimal results. |
| Immunogen | A peptide has been synthesized using human EPHB1/2 that is derived from Phospho-Tyr778/Tyr780. To create a similar content, the original text information should be rearranged in a manner that reflects the same meaning. |
| MW | 117KD |
| Properties | |
Concentration | 1mg/ml |
| purification | The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). |
| Tissue specificity | Preferentially expressed in brain. |
| Posttranslational modification | Phosphorylated. Autophosphorylation is stimulated by the ligand EFNB1. Required for interaction with SH2 domain-containing interactors, for activation of the MAPK/ERK and JUN signaling cascades and for ubiquitination by CBL.Ubiquitinated; (EFNB1)ligand-induced poly- and/or multi-ubiquitination by CBL is regulated by SRC and leads to lysosomal degradation. |
| Celluar localization | Cytosol;Endoplasmic reticulum;Endosome;Extracellular region or secreted;Plasma Membrane; |
| UniPort | P54762/P29323 |
Western blot analysis EPHB1/2 (Phospho-Tyr778/Tyr780) using serum treated K562 whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
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