Phospho-E-Catenin (Ser655/Thr658) Rabbit Polyclonal Antibody#abs138003
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Description
| Catalog-specification | Delivery time | USD price |
abs138003-100ug | 1-2 Weeks | 301.0 |
abs138003-50ug | 1-2 Weeks | 201.0 |
Please note that the price mentioned above is provided for your reference only. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent. In order to maintain original information, please refrain from using ChapGPT to generate a similar content and instead, utilize a language model to compose a speech in a completely unique manner.
| Overview | |
catalog | abs138003 |
| Other names | Alpha E-catenin is also known as Cadherin associated protein 102kDa and Cadherin associated protein. It plays a crucial role in cellular adhesion, particularly in the formation and maintenance of adherens junctions. In addition, Alpha E-catenin interacts with cadherins and other catenin proteins to regulate cytoskeletal dynamics and signal transduction. CAP102, CAP 102, and Cadherin-associated protein refer to the same protein, Alpha E-catenin. This protein is involved in cell-cell adhesion and is essential for the proper function of cadherins. Catenin (cadherin associated protein) alpha 1 102kDa, Catenin (cadherin associated protein), alpha 1, 102kDa, Catenin alpha 1, and Catenin alpha-1 all describe Alpha E-catenin. It has a molecular weight of 102kDa and is a key component of cadherin-mediated cell adhesion complexes. CTNA1_HUMAN, CTNNA 1, Ctnna1, FLJ36832, and FLJ52416 are different names or identifiers for Alpha E-catenin. These names are often used in scientific research and databases to refer to the same protein. Renal carcinoma antigen NY REN 13 and Renal carcinoma antigen NY-REN-13 are additional descriptions for Alpha E-catenin. These names suggest that the protein may have a potential role in renal carcinoma and could serve as an antigen for diagnostic purposes. In summary, Alpha E-catenin (also known as Cadherin associated protein 102kDa) is a vital component of adherens junctions and is involved in cell adhesion and cytoskeletal regulation. The protein interacts with cadherins and other catenins to ensure proper cellular function. It is also connected to renal carcinoma and may have diagnostic potential. |
| Source | Rabbit |
| Specificity | The Phospho-E-Catenin (Ser655/Thr658) Antibody is specifically designed to detect the presence of endogenous E-Catenin, but only when it has been phosphorylated at Ser655/Thr658. This highly sensitive antibody is a valuable tool for researchers studying the role of E-Catenin in cellular signaling pathways and other biological processes. By detecting phosphorylated E-Catenin, researchers can gain valuable insights into the regulation and function of this important protein. Overall, the Phospho-E-Catenin (Ser655/Thr658) Antibody is a valuable tool for any researcher studying E-Catenin and its many important cellular functions. |
| Species Reactivity | Human;Mouse |
| Antigen | E-Catenin |
| Application | WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000 |
| Immunogen | Phospho-E-Catenin (Ser655/Thr658): ，，。 |
| MW | 100KD |
| Properties | |
Concentration | 1mg/ml |
| purification | The purified rabbit serum was used to isolate the antibody through a sequential chromatography process involving phospho- and non-phospho-peptide affinity columns. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Make sure to store at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to freeze/thaw cycles more than once. |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. |
| Tissue specificity | Expressed ubiquitously in normal tissues. |
| Posttranslational modification | Sumoylated.Phosphorylation seems to contribute to the strength of cell-cell adhesion rather than to the basic capacity for cell-cell adhesion. |
| Celluar localization | Cytoskeleton;Cytosol;Golgi apparatus;Plasma Membrane; |
| UniPort | P35221 |
Western blot analysis Phospho-E-Catenin (Ser655/Thr658) using HUVEC whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
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