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Rabbit Anti-DZIP3 Polyclonal Antibody#abs141096

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Description

Catalog-specification	Delivery time	USD price
abs141096-100ug	1-2 Weeks	301.0
abs141096-50ug	1-2 Weeks	201.0

Overview
catalog	abs141096
Other names	DZIP3 is an E3 ubiquitin-protein ligase that interacts with DAZ protein 3, and is also known as hRUL138 or KIAA0675. This enzyme is a large RNA-binding ubiquitin ligase, with a molecular weight of 138 kDa. It plays an essential role in regulating protein degradation and turnover by adding ubiquitin molecules to target proteins. Thus, DZIP3 is a critical player in maintaining cellular homeostasis and is being extensively studied as a potential therapeutic target for various diseases. Overall, the functions and properties of DZIP3 are an exciting area of research with the potential to have a significant impact on human health.
Source	Rabbit
Specificity	The detection of total DZIP3 is facilitated by the DZIP3 Antibody, which effectively identifies the endogenous levels of this protein. In order to generate content that is highly similar to the original text, the information should be rearranged while maintaining the factual details.
Species Reactivity	Human;Rat
Antigen	DZIP3
Application	IHC: 1:50~1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000, WB 1:500~1:1000. The dilution ratios for various assays are as follows: for Western Blotting, the recommended dilution range is between 1:500 and 1:1000; Immunohistochemistry requires a dilution range of 1:50 to 1:200; for Immunofluorescence/Immunocytochemistry, the appropriate dilution ratios are between 1:100 and 1:500; and when performing an ELISA using peptides, the suggested dilution range is from 1:20000 to 1:40000.
Immunogen	A synthesized peptide.
MW	139 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the purification process of the antiserum through peptide affinity chromatography. Please rephrase the given information to produce highly similar content while respecting the original text.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the preservation of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is crucial to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	The solution contains Rabbit IgG in phosphate buffered saline with a pH of 7.4, 150mM NaCl, and 0.02% sodium azide. Additionally, it contains 50% glycerol and should be stored at -20 °C. This solution is stable for up to 12 months from the date of receipt, providing a convenient and reliable option for various research applications.
Target
Background	The E3 ubiquitin ligase proteins play a critical role in the process of protein degradation, as they are responsible for mediating ubiquitination and subsequent proteasomal breakdown of target proteins. These specialized proteins bind to an E2 ubiquitin-conjugating enzyme and accept ubiquitin in the form of a thioester, which is then transferred directly to the targeted substrates. Interestingly, E3 ubiquitin ligases are also known to possess the ability to specifically bind RNA, further highlighting their versatility and importance in many cellular processes. This unique skill set makes them valuable targets for research and drug development, as they may hold the key to unlocking new insights into the complex mechanisms of protein degradation and cellular regulation. Overall, E3 ubiquitin ligases are instrumental in maintaining proper protein homeostasis and are critical components of many cellular pathways.
Tissue specificity	Widely expressed at low level. Highly expressed in skeletal muscle, kidney and heart. Expressed at low level in placenta, lung, brain, liver and pancreas.
Celluar localization	Endoplasmic reticulum;
UniPort	Q86Y13