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Phospho-CD91 (Ser4520) Rabbit Polyclonal Antibody#abs140036

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Description

Catalog-specification	Delivery time	USD price
abs140036-100ug	1-2 Weeks	301.0
abs140036-50ug	1-2 Weeks	201.0

Overview
catalog	abs140036
Other names	The Alpha-2-macroglobulin receptor, also known as A2MR or CD91, is encoded by the apolipoprotein E receptor (APOER) gene. It is also referred to as low-density lipoprotein receptor-related protein 1(LRP1), low density lipoprotein receptor-related protein 1 intracellular domain (LRPICD) or LRP-85/LRP-515. LRP1 plays a significant role in several biological processes, including cellular signaling, protein degradation, endocytosis, and neurotransmission. LRP1 is a large transmembrane protein that belongs to the LDL receptor family. It is composed of several functional domains, including an extracellular ligand-binding domain, a transmembrane domain, and an intracellular domain. The extracellular domain of LRP1 is responsible for binding to various ligands such as alpha 2 macroglobulin (A2M), apolipoprotein E (apoE), tissue plasminogen activator (tPA), and matrix metalloproteinases (MMPs). Once bound to its ligands, LRP1 undergoes endocytosis, leading to the internalization of the ligand-LRP1 complex into the cell. This process serves as a significant mechanism for receptor-mediated endocytosis of several proteins, including A2M, tPA, and MMPs. LRP1 is also involved in the transportation of nutrients and lipids, including cholesterol and triglycerides, from the bloodstream to the cell. Moreover, LRP1 has been found to play a key role in various pathologies such as cancer, Alzheimer's disease, atherosclerosis, and diabetes. For instance, in Alzheimer's disease, LRP1 mediates the clearance of amyloid-beta protein from the brain. In atherosclerosis, LRP1 ensures the proper removal of low-density lipoprotein (LDL) from the bloodstream. In conclusion, LRP1 is a multifunctional receptor that plays an essential role in several biological processes. Its functionality and significance make it a promising target for the development of innovative therapeutic strategies for various pathologies.
Source	Rabbit
Specificity	The antibody CD91 (Phospho-Ser4520) is capable of detecting only the phosphorylated form of CD91 at Ser4520, which is present naturally in the organism's cells. Creating content based on this information requires rearranging the original text while maintaining its core message.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Bovine;Dog;Horse;
Antigen	CD91
Application	For Western Blot applications, the recommended dilution range is 1:1000-3000. As for Immunohistochemistry, a dilution range of 1:50-1:200 is suggested. When using ELISA for peptide detection, the optimal dilution range is 1:20000-1:40000. Always make sure to follow the recommended dilution ranges to get the best results for your experiments.
Immunogen	A peptide has been synthesized from human CD91, which is based on Phospho-Ser4520. To develop a similar content, the provided information needs to be rearranged and presented in a different way. A synthesized product has been created from human CD91, which utilizes Phospho-Ser4520 as its foundation.
MW	505kDa
Properties
Concentration	1mg/ml
purification	The affinity-purified antibody was derived from rabbit serum and was subjected to sequential chromatography on both phospho- and non-phospho-peptide affinity columns. This process ensured the high quality and specificity of the antibody, making it highly effective for a range of applications.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:11907044, PubMed:12888553, PubMed:12713657). Acts as an alpha-2-macroglobulin receptor (PubMed:26142438).
Tissue specificity	Most abundant in liver, brain and lung.
Posttranslational modification	Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane.The N-terminus is blocked.Phosphorylated on serine and threonine residues.Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.
Celluar localization	Cytosol;Endosome;Lysosome;Nucleus;Plasma Membrane;
UniPort	Q07954