Phospho-CD44 (Ser706) Rabbit Polyclonal Antibody#abs130813

abs130813-50ug

1-2 Weeks

201

abs130813-100ug

1-2 Weeks

301

Description

This gene encodes a critical cell-surface glycoprotein that plays a vital role in mediating a wide range of cellular processes such as cell-cell interactions, migration, and cell adhesion. It acts as a receptor for hyaluronic acid (HA) and can also interact with various other ligands, including matrix metalloproteinases (MMPs), collagens, and osteopontin. This protein provides an essential link in the communication between cells, allowing them to function together to promote various physiological functions. Its importance in maintaining cellular integrity and mediating tissue homeostasis cannot be overstated.

Other names

CD44 is a cell surface glycoprotein known as the CD44 antigen. It is also referred to as the CD44 molecule and is associated with the Indian blood group. CD44 serves as a receptor for extracellular matrix components and has a homing function. It is involved in lymphocyte adhesion and is a ligand for E- and L-selectin. CD44 is a proteoglycan that interacts with heparan sulfate and chondroitin sulfate. It is also known by other names such as HCELL, Hermes antigen, and phagocytic glycoprotein 1. The soluble form of CD44 is also present. Other related names for CD44 include IN, INLU-related p80 Glycoprotein, and hyaluronate receptor. CD44 has various isoforms and is associated with different cellular processes such as phagocytosis and cell migration.

Source

Rabbit

Specificity

CD44 Antibody specifically recognizes CD44 protein that has been phosphorylated at Serine 706, allowing for the detection of endogenous levels of this modified form. To reiterate, this antibody is designed to target CD44 when it is phosphorylated at Ser706.

Predictive reaction species

Xenopus;Rabbit;Pig;Dog;Sheep;Bovine;

Application

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- For western blotting, the recommended dilution range is 1:500-1:2000, while for immunofluorescence and immunocytochemistry, a dilution of 1:100-1:500 is suggested. When performing ELISA with a peptide, use a dilution range of 1:20000-1:40000 for optimal results.
- To obtain optimal results in western blotting, use a dilution range of 1:500-1:2000, whereas for immunofluorescence and immunocytochemistry, a dilution of 1:100-1:500 is recommended. When conducting ELISA with a peptide, the appropriate dilution range is 1:20000-1:40000.
- The dilution range for western blotting should be between 1:500-1:2000, while for immunofluorescence and immunocytochemistry, a dilution of 1:100-1:500 is optimal. For ELISA using a peptide, it is recommended to use a dilution range of 1:20000-1:40000.
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Properties

1mg/ml

Purification

The affinity-purified antibody was obtained from rabbit serum that underwent sequential chromatography on two distinct columns, one for phospho-peptides and the other for non-phospho-peptides. This specific process ensured a high degree of purification and resulted in a highly potent antibody.

Clonality

Polyclonal Antibody

To maintain the quality of your product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing as this could compromise its quality. Take care to follow these storage instructions carefully to ensure that your product remains usable for the duration of its shelf-life.

Storage buffer

This is Rabbit IgG in a solution of phosphate buffered saline, with a pH of 7.4, 150mM of NaCl, and 0.02% of sodium azide, with a 50% glycerol component. It is recommended to store this solution at a temperature of -20°C, as it is stable for up to 12 months from the date of receipt.

Target

Background

 Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).

Tissue specificity

Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.

Celluar localization

Cytosol;Extracellular region or secreted;Golgi apparatus;Plasma Membrane;

P16070