Rabbit Anti-TBX22 Polyclonal Antibody #abs130492

abs130492-50ug

1-2 Weeks

201

abs130492-100ug

1-2 Weeks

301

Description

The T-box gene family is highly conserved across phylogenetic lineages and includes genes that encode transcription factors essential for regulating developmental processes. Within this family, this particular gene is notable for its association with the X-linked disorder, Cleft palate with ankyloglossia, which suggests that it plays a crucial role in palatogenesis in humans. The common DNA-binding domain, the T-box, is shared among T-box genes and provides a structural basis for DNA-target recognition and regulation. Mutations in this gene have serious implications for proper development and underscore the importance of careful monitoring and therapeutic intervention for individuals affected by this condition.

Other names

TBX22 is a transcription factor that belongs to the T-box family. It is also known as T box protein 22 and is coded by the D230020M15Rik gene in humans. TBX22 is important for embryonic development, particularly in the formation of the palate and teeth. Mutations in this gene can lead to cleft palate and related abnormalities of the teeth. Other aliases for TBX22 include ABERS, CLPA, and CPX. The TBX22 protein is identified by the accession number TBX22_HUMAN and is an important mediator of genetic processes in development.

Source

Rabbit

Specificity

TBX22 Antibody detects endogenous levels of TBX22.

Species Reactivity

Human

Application

。WB1:5001:2000，IF/ICC1:1001:500，ELISA（）1:200001:40000。
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，。（WB），1:5001:2000。（IF/ICC），1:1001:500。，（ELISA），1:200001:40000。。
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Immunogen

A synthesized peptide derived from human TBX22.

Properties

Concentration

1mg/ml

Purification

Using the SulfoLink™ Coupling Resin, we employed peptide affinity chromatography to purify the antiserum.

Clonality

Polyclonal Antibody

Stability & Storage

To preserve the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles which could potentially compromise its integrity.

Storage buffer

The provided rephrased content:
To maintain its stability, Rabbit IgG is stored in phosphate buffered saline at pH 7.4, along with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is crucial to store it at a temperature of -20 °C. The product remains stable for up to 12 months from the date of receipt.

Target

Background

A key factor that plays an important role in developmental processes is the probable transcriptional regulator. It is a major contributor to palatogenesis, which is the formation of the palate during embryonic development. This regulatory protein is crucial for proper development and plays a critical role in determining important developmental outcomes.

Tissue specificity

Seems to be expressed at a low level.

Celluar localization

Nucleus;

UniPort

Q9Y458