Phospho-Calcium Sensing Receptor (Thr888) Rabbit Polyclonal Antibody#abs130921

abs130921-50ug

1-2 Weeks

201

abs130921-100ug

1-2 Weeks

301

Description

The CASR is an essential player in maintaining a stable level of calcium in the body. It acts as a sensing mechanism for the parathyroid and kidney, helping them to determine the concentration of calcium in the extracellular environment. Through its intricate role as a calcium sensor, the CASR plays a vital function in regulating various physiological processes in the body.

Other names

The calcium-sensing receptor, also known as Ca sensing receptor or Ca2+ sensing receptor 1, plays a crucial role in sensing extracellular calcium levels. It is encoded by the CASR gene in humans. The receptor, which is present on the surface of various cells, including parathyroid cells, has multiple functions related to calcium regulation.
The extracellular calcium-sensing receptor, as a precursor molecule, undergoes processing to generate the mature form. It is also referred to as the extracellular calcium-sensing receptor. The receptor is involved in the pathogenesis of several conditions, including hypocalciuric hypercalcemia 1 (HHC1) and severe neonatal hyperparathyroidism.
Another name for the calcium-sensing receptor is GPRC2A. It is widely expressed in different tissues and is responsible for sensing changes in extracellular calcium concentrations. By detecting variations in calcium levels, the receptor helps regulate parathyroid hormone secretion and maintain calcium homeostasis.
The calcium sensing receptor (CaSR) has been studied extensively in the context of familial hypocalciuric hypercalcemia (FHH). FHH is characterized by a malfunctioning CaSR, leading to impaired calcium sensing and consequently abnormal regulation of calcium metabolism.
The CaSR is also known as PCAR1, which stands for the parathyroid cell calcium sensing receptor 1. This name emphasizes its prominent role in parathyroid cells, where the receptor modulates the synthesis and secretion of parathyroid hormone in response to changes in extracellular calcium concentration.
Overall, the Ca sensing receptor, or CaSR, is a crucial molecular player in controlling calcium regulation and is implicated in various calcium-related disorders such as FHH and HHC1. Its ability to sense extracellular calcium levels makes it a valuable target for therapeutic interventions aimed at restoring calcium homeostasis.

Source

Rabbit

Specificity

The Antibody for Phospho-Calcium Sensing Receptor (Thr888) is able to identify the presence of Calcium Sensing Receptor in the body, but only in cases where it has been phosphorylated at Threonine 888. This means that, by studying the levels of this protein in the body, researchers can gain valuable insights into the body's response to changes in calcium levels. Ultimately, this could lead to new treatments for a range of conditions, including osteoporosis and kidney disease.

Predictive reaction species

Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine

Application

The recommended dilution ratios for WB are 1:500-1:2000, for IF/ICC are 1:100-1:500, and for ELISA (peptide) are 1:20000-1:40000. It is important to follow these dilutions to obtain accurate results.

The phosphorylation site of Threonine 888 is utilized to synthesize a synthesized peptide obtained from the human Calcium Sensing Receptor. It is crucial to ensure that the generated content remains highly similar to the original information. However, it is important to note that the generated text should be distinct and not follow the conversation style used by ChapGPT.

Properties

1mg/ml

Purification

The antibody was obtained by purifying rabbit serum through a series of chromatography techniques using affinity columns for both phospho and non-phospho peptides. The purification process allowed for the isolation of a highly specific and potent antibody.

Clonality

Polyclonal Antibody

To maintain its stability, it is recommended to store the product at a temperature of -20 °C for up to one year. It is important to avoid any repeated freeze and thaw cycles during storage. This will help to ensure that the product remains viable and effective for its intended use over an extended period of time. So, it is important to follow these storage guidelines carefully in order to maximize the lifespan and quality of the product.

Storage buffer

：IgG-20°C，pH7.4，150mM NaCl，0.02%50%。，12。

Target

Background

 G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547).

Tissue specificity

Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.

Celluar localization

Nucleus;Plasma Membrane;

P41180