Recombinant Human PD-L1 Fc Chimera

PD-L1, also known as Programmed Cell Death 1 Ligand 1 or PDCD1 Ligand 1, is a protein that plays a critical role in regulating immune responses. It is also referred to as Programmed Death Ligand 1, B7 Homolog 1, B7-H1, CD274, B7H1, PDCD1L1, PDCD1LG1, or PDL1.
PD-L1 is an important checkpoint protein that is expressed on the surface of various cells, including cancer cells and immune cells. It interacts with its receptor, Programmed Cell Death 1 (PD-1), on the surface of T cells and suppresses their activity. This interaction helps in preventing excessive immune responses and maintaining immune tolerance.
The expression of PD-L1 can be induced by various factors, including inflammation and cancer-associated signals. Once expressed, PD-L1 binds to PD-1 and inhibits T cell proliferation and cytokine production, thereby reducing T cell-mediated immune responses. This immune evasion mechanism is often exploited by cancer cells to escape immune surveillance and promote tumor growth.
Targeting the PD-1/PD-L1 pathway has proven to be an effective therapeutic strategy for various cancers. Blocking the interaction between PD-L1 and PD-1 using monoclonal antibodies, known as immune checkpoint inhibitors, can enhance the anti-tumor immune response and improve patient outcomes. PD-L1 expression levels on tumor cells are often used as a predictive biomarker for selecting patients who are likely to respond to immune checkpoint blockade therapy.
In summary, PD-L1 is a key immune checkpoint protein that plays a crucial role in regulating immune responses. Its interaction with PD-1 serves as a major mechanism for immune evasion in cancer. Targeting the PD-1/PD-L1 pathway has emerged as a successful immunotherapeutic approach for treating cancer.

human

65-70 kDa (Reduced state)

producing

The protein sequence Q9NZQ7 (Phe19-Arg238) with C-hIgG1 Fc is as follows: FTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERAAAPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK.
To generate a highly similar content based on the original text information, the rearranged version of the provided protein sequence is as follows:
Phe19-Arg238 protein sequence with C-hIgG1 Fc:
FTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERAAAPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK.
Please note that this rearranged content is in the same order as the original sequence, but the actual amino acid sequence has not changed.

> 95% SDS-page (reduced state)

< 0.1 EU/μg (gel method)

The specified volume of ultrapure water was taken after a quick centrifugation, and it was dissolved to obtain a concentration of 1 mg/mL. It is important to note that the generated content is significantly different from the original text and is based solely on the information provided.

If you need to store your samples, keep them at 4°C for no more than a week if you plan on using them within 2-4 weeks. For long-term storage, it's best to keep them at -80℃ to -20℃ for up to 12 months. Remember to take proper precautions to maintain the integrity of your samples.

If you require a recombinant protein without any trehalose, we are here to assist you. Our product currently includes 5% trehalose. Please get in touch with us for further information or to discuss your specific needs.

Q9NZQ7