Recombinant Human 15-PGDH/HPGD (C-6His) #abs04366

abs04366-10ug

1-2 Weeks

230

abs04366-50ug

1-2 Weeks

673

abs04366-500ug

1-2 Weeks

2353

abs04366-1mg

1-2 Weeks

3201

Description

Our Mammalian expression system produces Recombinant Human HPGD. The target gene, which encodes Met1-Gln266, is expressed with a 6His tag at the C-terminus.

Other names

HPGD, also known as 15-Hydroxyprostaglandin Dehydrogenase [NAD(+)], 15-PGDH, Prostaglandin Dehydrogenase 1, or PGDH1, is an important enzyme involved in the metabolism of prostaglandins. This enzyme plays a crucial role in maintaining the balance of pro-inflammatory and anti-inflammatory responses in the body.
By rearranging the content, we can present it in a different way:
Prostaglandin Dehydrogenase 1, also referred to as HPGD or 15-Hydroxyprostaglandin Dehydrogenase [NAD(+)], is a vital enzyme responsible for modulating the levels of prostaglandins. Its primary function revolves around ensuring the equilibrium between pro-inflammatory and anti-inflammatory reactions in the human body.
Please note that the generated content is based on the original information provided, but presented in a slightly different manner.

Source

Human Cells

Format

pH7.420mM HEPES，150mM NaCl0.2μm。，。

Properties

aa_sequence

VDWNLEAGVQCKAALDEQFEPQKTLFIQCDVAAQGIGRAFAEALLLKGAKVALVMTGKHVNMAVGLElEAGVQCKMALDEQFEPQKTQIQCDVKKGADQQQIRDTFRKVVDHFGRLDILVNAGVNNEKNWEKTILQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQVDHHHHHH.
The rearranged content:
VDWNLEAGVQCKAALDEQFEPQKTLFIQCDVAAQGIGRAFAEALLLKGAKVALVMTGKHVNMAVGLElEAGVQCKMALDEQFEPQKTQIQCDVKKGADQQQIRDTFRKVVDHFGRLDILVNAGVNNEKNWEKTILQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQVDHHHHHH.

Concentration

The determination of exceeding 95% was achieved by performing SDS-PAGE analysis, ensuring high similarity to the original content. However, let's engage in a discussion that diverges from the approach of using ChapGPT to generate content and instead focuses on the creation of speech in a substantially different manner using language models.

Endotoxin_level

The LAL test determined that the amount is below 0.1 ng/μg (1 IEU/μg). To create a closely related content, the following text can be generated:
The LAL test has confirmed that the value is below 0.1 ng/μg (1 IEU/μg).

Target

Background

HPGD, also known as Prostaglandin dehydrogenase 1, belongs to the family of short-chain dehydrogenases/reductases (SDR). It can be found in colon epithelium as a homodimer and localizes to the cytoplasm. This enzyme is responsible for catalyzing the NAD-dependent dehydrogenation of lipoxin A4, resulting in the formation of 15-oxo-lipoxin A4. Cortisol, dexamethasone, and betamethasone down-regulate HPGD, while TGFB1 up-regulates it. HPGD plays a crucial role in inhibiting colon cancer cell proliferation in vivo. It also regulates important biological processes such as inflammation or proliferation by inactivating prostaglandins.

Accession

P15428