Recombinant 2019-nCoV S1 Protein (C-Fc) #abs04704

abs04704-50ug

1-2 Weeks

310

abs04704-500ug

1-2 Weeks

2328

abs04704-1mg

1-2 Weeks

3491

Description

The Mammalian expression system is responsible for producing the Recombinant 2019-nCoV S1 Protein, with the target gene encoding Gln14-Arg685. This protein has a Fc tag positioned at the C-terminus for optimal performance. To produce a similarly informative message, you could rearrange the text to read:
Our cutting-edge Mammalian expression system is utilized in the production of Recombinant 2019-nCoV S1 Protein. The target gene, which encodes Gln14-Arg685, is expertly expressed and includes a vital Fc tag at the C-terminus.

Accession: QHD43416.1

Other names

The S1 protein is a crucial component of the 2019-nCoV virus, commonly known as the coronavirus. This vital protein is responsible for facilitating the virus' entry into human cells, allowing it to cause infection. Cov S1 protein has been extensively studied since the outbreak of the pandemic, with researchers worldwide working hard to formulate effective treatments and vaccines against it. Understanding the structure and function of the coronavirus S1 protein is essential in developing strategies to combat COVID-19 and protect public health. Despite the ongoing challenges posed by this virus, healthcare professionals and scientists remain committed to advancing our knowledge of the S1 protein and finding innovative ways to combat the COVID-19 pandemic.

Source

Human Cells

MW

The molecular weight of AP is approximately 102.2kDa. However, when subjected to reducing conditions, the actual molecular weight ranges between 130-140kDa. It is important to note that this information is based on the original text and has been rearranged to convey the same meaning in a different way.

Format

pH7.4PBS 0.2μM。，，。

Properties

Purification

Affinity purification chromatography.

Concentration

The result of reducing SDS-PAGE showed that the protein purity is over 90%. Please create a comparable message by rephrasing the original text without duplicating the exact wording or terminologies.

Activity

The ED50 of 2019-nCoV S1 Protein-Fc is 0.85 ug/ml.

Stability & Storage

The recommended storage temperature for reconstituted protein solution is -20°C or below. It is important to ensure that the solution is kept at this temperature for optimal preservation.

Target

Background

Protein S (PROS1) is a glycoprotein found in various cell types. It is known to play a role in several biological processes, including blood clotting, cell death, cancer development and progression, and the body's innate immune response. Several receptors, such as ACE2, angiotensin-converting enzyme 2, DPP4, and CEACAM, have been identified as binding sites for Protein S.
Coronaviruses, including the severe acute respiratory syndrome (SARS), rely on their spike (S) glycoprotein to attach to and infect host cells. The spike protein of SARS-CoV alone can initiate membrane fusion, enabling the virus to enter and fuse with cells. It is also an important target for developing entry inhibitors and vaccines due to its immunogenic properties.
Recent studies have shown that the 2019 novel coronavirus (2019-nCoV) can infect respiratory epithelial cells by interacting with the human ACE2 receptor. The spike protein consists of two subunits, S1 and S2. S1 contains a receptor binding domain (RBD) responsible for recognizing the cell surface receptor, while S2 contains essential elements for membrane fusion.
The spike protein plays a crucial role in inducing neutralizing antibodies, activating T-cell responses, and establishing protective immunity against the virus. Understanding the mechanisms of the spike protein and its interactions with host receptors is essential in developing effective therapeutic interventions and vaccines against coronavirus infections.