Human Alpha-2 Macroglobulin Protein, #abs44063307

abs44063307-200ug

4 weeks

180

abs44063307-1mg

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447

abs44063307-10mg

4 weeks

3383

Description

Alpha-2 Macroglobulin, a large plasma protein, acts as an inhibitor for serine proteases, effectively preventing coagulation by inactivating thrombin and Kallikrein. Additionally, it inhibits fibrinolysis by inactivating plasmin and plays a role in transport processes. Produced by the liver, Alpha-2 Macroglobulin is composed of four identical subunits that are bound together by -S-S- bonds. It possesses the ability to inhibit various proteinases, including serine, cysteine, aspartic, and metalloproteinases.
One notable feature of Alpha-2 Macroglobulin is its structure, which includes a 35 amino acid "bait" region. Proteinases bind and cleave this region, subsequently becoming bound to Alpha-2 Macroglobulin. The proteinase-A2M complex is recognized by macrophage receptors, leading to its clearance from the system. Furthermore, A2M binds to and removes active forms of gelatinases, such as MMP-2 and MMP-9, from circulation using scavenger receptors present on phagocytes.
In nephrotic syndrome, a condition characterized by the leakage of smaller blood proteins from the kidneys, the levels of Alpha-2 Macroglobulin are elevated. Due to its large size, A2-macroglobulin remains in the bloodstream. The increased production of all proteins causes an increase in A2-macroglobulin concentration. Additionally, chronic renal failure may contribute to amyloid formation by Alpha-2 Macroglobulin.
It is worth noting that A2M levels are elevated in conditions such as cirrhosis, pregnancy, and diabetes.

Other names

One of the important proteins found in the human body is known as alpha-2 macroglobulin or A2M. Sometimes also referred to as alpha-2-macroglobulin, alpha-2-M or CPAMD5, this protein is an essential component of our blood plasma. It is also known by some other names such as FWP007, S863-7, alpha 2M and DKFZp779B086.
Alpha-2 macroglobulin is an important protein that helps to protect us against various harmful substances. It acts as a defense mechanism, trapping enzymes and other toxins and neutralizing them before they can cause damage to our body. This is why it is often referred to as a "trap and neutralize" protein.
In addition to its protective role, alpha-2 macroglobulin is also involved in several other essential functions in our body. For example, it plays a role in various metabolic processes and helps to regulate our immune system.
Overall, alpha-2 macroglobulin is a highly important protein that is essential for our wellbeing. While it may have several different names, its crucial role in our body remains the same, and we must ensure that we maintain optimal levels of this vital protein for good health.

Source

Human Plasma

MW

725 kDa

Appearance

A powder that has been lyophilized (freeze-dried) and filtered to be sterile is available in white. Can you produce comparable content by rearranging the preceding sentence, guaranteeing that the generated text is derived from the original information?

Properties

Concentration

96%

Stability & Storage

To maintain the stability of Human Alpha-2 Macroglobulin, it is recommended to store it between 2-8℃. Freezing is not allowed. Although it can be kept at room temperature for up to 3 weeks, it is better to store it properly to avoid any potential degradation or loss of activity. So, make sure that you follow the guidelines carefully to get the most out of this important biological molecule. Remember, taking good care of your samples is key to achieving accurate and reproducible results in your research.