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Rabbit anti-NPSR1 Polyclonal Antibody#abs133201

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Description

Catalog-specification	Delivery time	USD price
abs133201-100ug	1-2 Weeks	301.0
abs133201-50ug	1-2 Weeks	201.0

Overview
catalog	abs133201
Other names	The text provided consists of various names and acronyms related to different G protein-coupled receptors. These receptors are involved in various physiological processes and have been associated with conditions such as asthma susceptibility, neuropeptide signaling, and vasopressin receptor-related functions. By rearranging the provided content, we can generate the following information: G protein-coupled receptor 154 (GPR154), also known as G protein-coupled receptor for asthma susceptibility, is a receptor involved in asthma susceptibility. It is also referred to as PGR14 and GPRA. Another important receptor in this family is the Neuropeptide S receptor 1 (NPSR1), which is responsible for binding and signaling neuropeptide S. It is also known as NPSR or NPS receptor. Furthermore, we have the Vasopressin receptor-related receptor 1 (VRR1), which plays a role in vasopressin receptor-related functions. These receptors, with their distinct names and acronyms, contribute to our understanding of various physiological processes and may have implications in disease conditions such as asthma susceptibility and neuropeptide signaling.
Source	Rabbit
Specificity	The endogenous levels of total NPSR1 can be detected by the NPSR1 antibody. The content above can be rearranged as follows: To determine the total NPSR1 levels within an organism, the NPSR1 antibody serves as a reliable detection tool.
Species Reactivity	Human;Mouse;Rat
Antigen	NPSR1
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	43 kDa;
Properties
Concentration	1mg/ml
purification	Purification of the antiserum involved utilizing SulfoLink™ Coupling Resin through peptide affinity chromatography. The end result was a highly purified antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Please make sure to avoid repeated freeze/thaw cycles when storing at -20 °C for a year. It is important to store the product in this temperature consistently without subjecting it to fluctuating temperatures.
Storage buffer	The composition of Rabbit IgG comprises phosphate buffered saline with a pH value of 7.4. This is supplemented with 150mM of NaCl, 0.02% sodium azide, and 50% glycerol to provide a stable form of the protein.
Target
Background	G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca2+ stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.
Tissue specificity	Isoform 4 is ubiquitous; it is detected in glandular epithelia of bronchus, stomach, small intestine, colon, uterus, esophagus, spleen, kidney, pancreas, prostate and breast. Isoform 1 is detected in uterus, colon and prostate, and in the smooth muscle cell layer in bronchial and arterial walls (at protein level) (PubMed:15947423). Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, its expression is consistently stronger in asthma patients.
Celluar localization	Plasma Membrane;
UniPort	Q6W5P4