Rabbit Anti-Connexin 45 Polyclonal Antibody#abs131184

abs131184-50ug

1-2 Weeks

201

abs131184-100ug

1-2 Weeks

301

Description

Connexons, which are transmembrane channels, form clusters within gap junctions. They are closely packed together and allow for the diffusion of low MW materials from one cell to a neighboring cell. The structure of gap junctions is essential to facilitate communication and exchange of substances between adjacent cells.

Other names

Connexin 45, also known as CX 31.9 or Cx45, is a protein encoded by the GJA7 gene. It is a member of the connexin family of gap junction proteins, which play a key role in the exchange of ions and small molecules between adjacent cells. Connexin 45 is expressed in various tissues, including the heart, brain, and skin. It forms gap junction channels that allow for communication between cells, helping to coordinate various physiological processes. In addition to its role in intercellular communication, connexin 45 has also been implicated in various diseases, including hearing loss, skin disorders, and cardiac arrhythmias. Further research into the function and regulation of connexin 45 may provide insights into the pathogenesis of these and other disorders.

Source

Rabbit

Specificity

The detection of total Connexin 45 is achievable using the Connexin 45 Antibody, which targets the endogenous levels of the protein. This means that the antibody is able to recognize and bind to the entire pool of Connexin 45 present in a sample.

Predictive reaction species

Pig;Dog;

Application

，：
WB：1:500-1:2000Western Blot。
IHC：1:50-1:200。
IF/ICC：1:100-1:500/。
ELISA（）：1:20000-1:40000。

Connexin 45。，。，。

Properties

1mg/ml

Purification

SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum.

Clonality

Polyclonal Antibody

To preserve the content for a long period of time, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is advised to refrain from subjecting the content to repeated freeze/thaw cycles, as this could cause damage to the content. Please ensure that the content is stored securely and under proper conditions to maintain its integrity.

Storage buffer

This product contains Rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4, 150mM of NaCl, 0.02% of sodium azide, and 50% of glycerol. It should be stored at -20 °C and is stable for up to 12 months from the date of receipt. Please be mindful of these conditions to ensure that the product remains potent and effective.

Target

Background

A collection of paired transmembrane channels, known as connexons, forms a gap junction that allows small molecules to diffuse between neighboring cells. The closely packed clusters of these channels create a pathway for low molecular weight substances to move freely from one cell to another.

Celluar localization

P36383