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Rabbit Anti-V-ATPase D1 Polyclonal Antibody#abs138149

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Description

Catalog-specification	Delivery time	USD price
abs138149-100ug	1-2 Weeks	301.0
abs138149-50ug	1-2 Weeks	201.0

Overview
catalog	abs138149
Other names	The 32 kDa accessory protein, also known as V-ATPase AC39 subunit or VATX, is an important part of the H+ transporting lysosomal (vacuolar proton pump). This protein is encoded by the ATP6D gene and is also referred to as ATP6DV or ATP6V0D1. It is a subunit of the V-ATPase, which plays a vital role in the transportation of protons across biological membranes. Another name for this protein is ATPase H+ transporting lysosomal 38kD V0 subunit d or ATPase H+ transporting lysosomal 38kDa V0 subunit d1. It is also known as ATPase H+ transporting lysosomal V0 subunit d1 and H(+) transporting two sector ATPase subunit D. The protein is about 40 kDa in size and is considered an accessory protein of the V-ATPase. The V-ATPase subunit D is required for the proper functioning of the vacuolar proton pump. It is involved in the regulation of pH levels within the lysosomes and other cellular compartments. Additionally, it has been shown to play a role in membrane fusion events and the proper sorting of proteins within the endosomal system. The V-ATPase subunit D is highly conserved across evolutionary species, indicating its critical role in cellular homeostasis. Its dysfunction has been linked to a number of diseases, including osteopetrosis, renal tubular acidosis, and neurodegenerative disorders. In conclusion, the V-ATPase subunit D, or ATP6D, is an essential component of the H+ transporting lysosomal pump. It plays a critical role in the regulation of pH levels and protein sorting within the endosomal system and is implicated in a number of human diseases.
Source	Rabbit
Specificity	The V-ATPase D1 Antibody is designed to specifically recognize and measure the levels of total V-ATPase D1 protein present in cells. This antibody can reliably detect endogenous levels of V-ATPase D1, providing valuable insights into its expression and function. By rearranging the information provided in the original text, we can convey the same message in a slightly different manner.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Zebrafish;Chicken;Rabbit;Pig;Dog;Horse;Bovine;Sheep;
Antigen	V-ATPase D1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	V-ATPase D1。，。
MW	40 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed for peptide affinity chromatography in order to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).
Tissue specificity	Ubiquitous.
Celluar localization	Endosome;Extracellular region or secreted;Lysosome;Plasma Membrane;
UniPort	P61421