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Rabbit Anti-TRPS1 Polyclonal Antibody#abs133769

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Description

Catalog-specification	Delivery time	USD price
abs133769-100ug	1-2 Weeks	301.0
abs133769-50ug	1-2 Weeks	201.0

Overview
catalog	abs133769
Other names	The TRPS1 protein, also known as Zinc Finger Transcription Factor TRPS1 or GATA Binding 1 Transcriptional Repressor, is associated with Tricho-rhino-phalangeal Syndrome Type I (TRPS I) in humans. TRPS I is a rare genetic disorder that affects bone development, causing abnormalities in the fingers, nose, and skull. The TRPS1 gene plays a vital role in regulating the growth and development of bone tissue. Furthermore, Zinc Finger Protein GC79 is another name for TRPS1, a zinc finger transcription factor that binds to DNA and influences gene expression. TRPS1 is responsible for the regulation of numerous genes that affect cell growth and differentiation. The TRPS1 protein has been implicated in several developmental disorders and cancers, making it a significant target for therapeutic interventions. In conclusion, the TRPS1 protein is an essential regulator of bone development and gene expression. It plays a crucial role in controlling cell growth and differentiation and is associated with genetic disorders and cancers. Further research on TRPS1 will lead to a better understanding of bone development and may open up new avenues for therapeutic interventions in developmental disorders and cancers.
Source	Rabbit
Specificity	The TRPS1 Antibody is capable of identifying the complete TRPS1 protein that naturally occurs within a cell. We can use this antibody to determine the overall levels of TRPS1 in an organism.
Species Reactivity	Human;Mouse
Antigen	TRPS1
Application	The suggested dilution range for the IHC assay is 1:50 to 1:200. For Western blotting, the recommended dilution range is 1:500 to 1:2000. Lastly, when performing ELISA with a peptide, the dilution range should be between 1:20000 and 1:40000. It is important to adhere to these dilution guidelines to ensure accurate and reliable results in these experimental techniques.
Immunogen	A synthesized peptide.
MW	0 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. A highly similar statement can be generated by rearranging the content and retaining the core information, without directly copying the original text.
Clonality	Polyclonal Antibody
Stability & Storage	The recommended storage condition for a year is -20 °C. It is important to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	The storage conditions for Rabbit IgG are as follows: it should be kept in phosphate buffered saline at a pH of 7.4, with a concentration of 150mM NaCl. Additionally, it should contain 0.02% sodium azide and 50% glycerol. It is recommended to store it at a temperature of -20°C. The stability of this product is guaranteed for a period of 12 months from the date of receipt.
Target
Background	Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.
Tissue specificity	Ubiquitously expressed in the adult. Found in fetal brain, lung, kidney, liver, spleen and thymus. More highly expressed in androgen-dependent than in androgen-independent prostate cancer cells.
Posttranslational modification	Sumoylated. Sumoylation in the repressor domain inhibits the transcription repression activity. Sumoylation on Lys-1201 is the major site. Appears to be sumoylated on multiple sites.
Celluar localization	Nucleus;
UniPort	Q9UHF7

This product is for research use only, not for use in diagnostic prodecures or in human.

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