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Rabbit Anti-TPBG Polyclonal Antibody#abs137879

Please note that the mentioned price is only for your reference. For the detailed price, we kindly request you to contact our seller, Vecent. Western blot analysis TPBG using NIH-3T3 whole cell lysates This product is for research use only, not for use in diagnostic prodecures or in human.

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Description

Catalog-specification	Delivery time	USD price
abs137879-100ug	1-2 Weeks	301.0
abs137879-50ug	1-2 Weeks	201.0

Please note that the mentioned price is only for your reference. For the detailed price, we kindly request you to contact our seller, Vecent.

Overview
catalog	abs137879
Other names	The 5T4 oncofetal antigen, also known as the 5T4 oncofetal trophoblast glycoprotein or the 5T4 oncotrophoblast glycoprotein, is a glycoprotein expressed in several types of cancer cells. It is also referred to as 5T4AG, AW495680, M6P1, TPBG, TPBG_HUMAN and Trophoblast glycoprotein. This protein is typically associated with trophoblasts, the cells that form during pregnancy, but it is also found in various cancer cells. The 5T4 oncofetal antigen has become a target for cancer vaccines and antibody-based therapies due to its role in cancer progression and metastasis. Understanding the role of this protein may help researchers to develop new therapies for cancer patients that could be more effective than existing treatments.
Source	Rabbit
Specificity	The TPBG Antibody is capable of recognizing the overall levels of TPBG in the body. This implies that it can detect the TPBG protein that originates from within the organism itself. To generate a similar content, the information from the initial text should be rearranged while ensuring that the meaning and context remain intact.
Species Reactivity	Human;Mouse
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Bovine;Sheep;
Antigen	TPBG
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human TPBG.
MW	46 kDa
Properties
Concentration	1mg/ml
purification	By utilizing SulfoLink™ Coupling Resin, the antiserum was refined through peptide affinity chromatography. This process resulted in a highly purified substance, specifically targeted and extracted for its intended purpose.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. To maintain its efficacy, it is important to avoid subjecting it to repeated freeze/thaw cycles.
Storage buffer	This product contains rabbit IgG solubilized in phosphate buffered saline with a pH of 7.4. In addition, it is supplemented with 150mM sodium chloride, as well as 0.02% sodium azide and 50% glycerol to preserve quality during storage at -20°C. This solution is guaranteed to be stable for up to 12 months, starting from the day of purchase.
Target
Background	May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.
Tissue specificity	Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.
Posttranslational modification	Highly glycosylated.
Celluar localization	Endoplasmic reticulum;Plasma Membrane;
UniPort	Q13641