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Rabbit Anti-TNK1 Polyclonal Antibody#abs133063

Description

Catalog-specification	Delivery time	USD price
abs133063-50ug	1-2 Weeks	201.0
abs133063-100ug	1-2 Weeks	301.0

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Overview
catalog	abs133063
Description	This gene is associated with the inhibition of cell growth and possesses tumor suppressor characteristics. Its main role is to regulate the Ras-MAPK pathway in a negative manner. Additionally, it is believed to participate in signaling pathways that are widely utilized during fetal development, as well as in adult tissues and cells of the lymphohematopoietic system. A possible specific function could be in phospholipid signal transduction.
Other names	Tyrosine kinase non-receptor 1 (TNK1), also known as non-receptor tyrosine protein kinase TNK1, is an enzyme encoded by the TNK1 gene in humans. It belongs to the family of non-receptor tyrosine kinases and plays a key role in embryonic stem cells. Additionally, it has been demonstrated to lack the CD38 marker, which is often used to identify certain cell receptors. The enzyme has a molecular weight of approximately 90 kDa and a specific activity of 2.7.10.2. It is also known as kinase of embryonic stem cells or Kos1, and has been designated MGC46193 in the NCBI database.
Source	Rabbit
Specificity	The TNK1 antibody is capable of detecting total TNK1 levels in the body as it can recognize and bind to the endogenous TNK1.
Species Reactivity	Human;Mouse
Antigen	TNK1
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	72 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was purified through peptide affinity chromatography. It ensured that the resulting content was highly identical to the original text information.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.
Tissue specificity	Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain.
Posttranslational modification	Autophosphorylated on tyrosine residues.
Celluar localization	Cytosol;Plasma Membrane;
UniPort	Q13470