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Rabbit Anti-TAOK2 Polyclonal Antibody#abs133062

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Description

Catalog-specification	Delivery time	USD price
abs133062-100ug	1-2 Weeks	301.0
abs133062-50ug	1-2 Weeks	201.0

Overview
catalog	abs133062
Description	Isoform 1 of this protein plays a crucial role in apoptotic morphological changes, including membrane blebbing, cell contraction, and apoptotic bodies formation. Its activation of MAPK8/JNK and nuclear localization of the C-terminally truncated isoform 1 are necessary for this function, which may be associated with the mitochondrial CASP9-dependent death pathway. The JNK MAP kinase pathway is specifically activated by isoform 1 via MKK3 and MKK6 kinases. In addition, it binds to microtubules and affects their organization and stability, independently of its kinase activity. Furthermore, it can prevent MAP3K7-mediated activation of IKKA, and therefore, NF-kappa-B activation, but not that of JNK. Isoform 2, on the other hand, is required for PCDH8 endocytosis, which is involved in homophilic interactions between PCDH8 extracellular domains. This leads to phosphorylation and activation of MAPK14/p38 MAPK, which phosphorylates isoform 2, resulting in PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. Isoform 1 also phosphorylates itself, MBP, activated MAPK8, and tubulins and plays a role in the osmotic stress-MAPK8 pathway.
Other names	1110033K02Rik is also known as B230344N16, hKFC C, hKFC-C, KIAA0881, Kinase from chicken homolog C, MAP3K17, mKIAA0881, Prostate derived STE20 like kinase 1, Prostate derived STE20 like kinase PSK, Prostate derived sterile 20 like kinase 1, Prostate-derived STE20-like kinase 1, PSK 1, PSK, PSK-1, PSK1, PSK1 beta, Serine/threonine protein kinase TAO2, Serine/threonine-protein kinase TAO2, TAO 1, TAO 2, TAO kinase 2, TAO1, TAO2, TAOK 2, Taok2, TAOK2_HUMAN, Thousand and one amino acid protein 2, Thousand and one amino acid protein kinase, and UNQ2971/PRO7431.
Source	Rabbit
Specificity	The detection of total TAOK2 at its endogenous levels is possible using the TAOK2 antibody. To provide a similar content, the information can be rearranged as follows: The TAOK2 antibody is capable of accurately identifying the complete TAOK2 protein in its natural concentrations found within an organism.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Horse;Bovine;
Antigen	TAOK2
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	120 kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation.
Tissue specificity	Ubiquitously expressed, with a higher level of expression in testis and brain.
Posttranslational modification	Isoforms 1 and 2 are autophosphorylated.C-terminal cleavage of isoform 1 and subsequent nuclear localization requires CASP9 activity.Autophosphorylated. Phosphorylated by ATM.Isoform 2: Phosphorylated on Ser-1031 by MAPK14. This phosphorylation is required PCDH8 for endocytosis (By similarity).
Celluar localization	Cytoskeleton;Cytosol;Nucleus;
UniPort	Q9UL54