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Rabbit Anti-TNIP3 Polyclonal Antibody#abs138603

Description

Catalog-specification	Delivery time	USD price
abs138603-100ug	1-2 Weeks	301.0
abs138603-50ug	1-2 Weeks	201.0

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Overview
catalog	abs138603
Other names	NF kappa B activation 3 binding inhibitor, also known as ABIN 3 or ABIN 3 beta, is a protein encoded by the FLJ21162 gene. It is also referred to as LIND (Listeria induced gene protein), as it is induced during Listeria infection. TNFAIP3 interacting protein 3, or TNIP3, is another name for this protein. There is also a beta isoform of TNIP3, known as TNIP3 beta. These proteins play a role in regulating NF kappa B activation, a critical pathway involved in inflammation and immune response. The binding of ABIN 3 to NF kappa B helps to inhibit its activation, thereby modulating the immune and inflammatory processes.
Source	Rabbit
Specificity	The TNIP3 Antibody is designed to recognize the entire quantity of endogenous TNIP3. To create similar content based on the original text, it can be restated as "The total levels of TNIP3 within an organism can be detected by using the TNIP3 Antibody, which is equipped to identify endogenous forms of this protein." A different approach may be to say "The TNIP3 Antibody is capable of detecting the full complement of endogenous TNIP3 present in an organism, providing a valuable method for examining the expression of this protein."
Species Reactivity	Human;Mouse
Antigen	TNIP3
Application	We recommend dilutions of 1:1000-3000 for western blotting, 1:200 for immunohistochemistry, and 1:20000-1:40000 for ELISA using peptides. These dilutions will ensure accurate and reliable results. It is essential to note that proper sample preparation and handling are necessary for successful outcomes. Follow the manufacturer's instructions for best practices and quality control.
Immunogen	A synthesized peptide derived from human TNIP3.
MW	39 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. An efficient method, this technique allowed for the isolation of the desired antibodies and removal of impurities. The purified antiserum was then ready for further use in diagnostic or therapeutic applications.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, it is recommended to store the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to multiple freeze/thaw cycles.
Storage buffer	The storage conditions for Rabbit IgG are as follows: it should be kept in phosphate buffered saline (pH 7.4) containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The recommended storage temperature is -20 °C. This product is stable for a period of 12 months starting from the date of receipt.
Target
Background	Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.
Tissue specificity	Highly expressed in lung, lymph node, thymus and fetal liver. Expressed at lower levels in bone marrow, brain, kidney, spleen, leukocytes and tonsils. Could be detected in heart, salivary gland, adrenal gland, pancreas, ovary and fetal brain. High levels detected in liver, colon, small intestine, muscle, stomach, testis, placenta, thyroid, uterus, prostate, skin and PBL.
Celluar localization	Cytosol;
UniPort	Q96KP6