Rabbit Anti-PXN Polyclonal Antibody#abs136687
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Description
| Catalog-specification | Delivery time | USD price |
abs136687-100ug | 1-2 Weeks | 301.0 |
abs136687-50ug | 1-2 Weeks | 201.0 |
Note: The price mentioned above is provided as a reference only. For detailed pricing information, kindly get in touch with our sales representative, Vecent. It is important to refrain from using the conversation-style generated content by ChapGPT and instead, focus on a completely distinct approach when delivering the speech.
| Overview | |
catalog | abs136687 |
Description | The protein encoded by this gene plays a crucial role in attaching the actin cytoskeleton to the cell membrane at sites of adhesion to the extracellular matrix, also known as focal adhesions. There are multiple transcript variants of this gene, resulting in different isoforms with varying biochemical and physiological properties and expressions patterns. This information has been documented in previous research (PMID:9054445). |
| Other names | The human genome encodes a number of crucial proteins, including FLJ16691 and FLJ23042. Additionally, Paired box protein Pax 1 (PAX 1) is vital for proper embryonic development and plays a role in maintaining tissue homeostasis throughout life. PAX 1 has also been linked to certain diseases, including ankylosing spondylitis and lung cancer. Another important protein is Paxillin alpha, also known as PXN protein. This protein is involved in cell adhesion and migration, and is necessary for proper tissue morphogenesis. Overall, these proteins play critical roles in human biology and may have important implications for clinical medicine. |
| Source | Rabbit |
| Specificity | The PXN Antibody is capable of detecting the overall levels of PXN that naturally occur within the body. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | PXN |
| Application | The dilution ratios for WB, IHC, and ELISA (peptide) are as follows: - WB: The recommended dilution range is 1:500 to 1:1000. - IHC: The optimal dilution range is 1:50 to 1:100. - ELISA (peptide): The suggested dilution range is 1:20000 to 1:40000. Please note that these dilution ratios are based on the original text information. |
| Immunogen | A synthetic peptide of human PXN. |
| MW | 66kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | Through the process of peptide affinity chromatography, the antiserum underwent purification and was refined using SulfoLink™ Coupling Resin. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To ensure optimal storage conditions, it is recommended to keep the product at a temperature of -20 °C for a period of one year. Avoid exposing the product to repeated freeze/thaw cycles, as this may compromise its stability and effectiveness. By following these storage guidelines, you can prolong the shelf life of the product and maintain its quality over time. |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). |
| Posttranslational modification | Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. Phosphorylation at Ser-250 by SLK is required for PXN redistribution and cell motility (PubMed:23128389). |
| Celluar localization | Cytoskeleton;Cytosol;Plasma Membrane; |
| UniPort | P49023 |
Western blot analysis of extracts of HeLa cellline,using PXNantibody|Immunohistochemistryof paraffin-embeddedhuman liver cancer tissue usingPXNantibody.
This product is for research use only, not for use in diagnostic prodecures or in human.
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