Rabbit Anti-PARD6A Polyclonal Antibody#abs136686
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Description
| Catalog-specification | Delivery time | USD price |
abs136686-100ug | 1-2 Weeks | 301.0 |
abs136686-50ug | 1-2 Weeks | 201.0 |
Please note: the price provided is for reference purposes only. For detailed pricing information, please reach out to our seller, Vecent. In order to produce content that is distinct from the original text and in compliance with the requested approach, I will refrain from using ChapGPT's conversation generation method and instead provide a speech formulated in a completely different manner.
| Overview | |
catalog | abs136686 |
Description | This particular gene is a part of the PAR6 family and its function is to encode a protein that contains a PDZ domain (PSD95/Discs-large/ZO1) and a CRIB domain (semi-Cdc42/Rac interactive binding). Found in the cell membrane, this protein plays a crucial role in processes like asymmetrical cell division and cell polarization as a component of a multi-protein complex. Additionally, it is involved in the epithelial-to-mesenchymal transition (EMT), which is responsible for the invasive phenotype observed in metastatic carcinomas. Different isoforms of this protein have been identified through alternative transcriptional splice variants. In summary, this gene and its protein product contribute to essential cellular processes and have implications in cancer progression. |
| Other names | Alpha homologs of Par 6 partitioning defective 6 (0710008C04Rik, 2610010A15Rik) are crucial regulators of cell polarity. They play a vital role in various organisms, including Caenorhabditis elegans. These homologs are known by multiple names such as PAR 6A, PAR-6 alpha, or PAR6. They are also referred to as par-6 family cell polarity regulator alpha. Another term used for these homologs is Partitioning Defective 6 homolog alpha C elegans or PAR-6C. Additionally, they are recognized as partitioning-defective protein 6, C. elegans, homolog of, alpha, or simply Pard6a. Furthermore, they are associated with a Tax interacting protein called TIP 40 or TAX40. To sum up, Par 6 partitioning defective 6 homolog alpha homologs are vital for cell polarity regulation and are known by various names, including PAR6A, PAR-6 alpha, PAR6C, Pard6a, partitioning-defective protein 6, TIP 40, or TAX40. |
| Source | Rabbit |
| Specificity | The total PARD6A levels in an organism can be accurately measured using the PARD6A Antibody. This specific antibody is capable of detecting the endogenous levels of total PARD6A. By utilizing this antibody, researchers can obtain reliable data regarding the expression of PARD6A within a biological system. It is an effective tool in studying the presence and quantity of total PARD6A, providing valuable insights into its functions and potential implications in various biological processes. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Pig;Rabbit;Sheep;Dog;Bovine;Horse; |
| Antigen | PARD6A |
| Application | The recommended dilution for this antibody in Western blotting is between 1:500 and 1:2000, for immunohistochemistry it is between 1:50 and 1:100, and for ELISA using peptide it is between 1:20000 and 1:40000. Please ensure adequate dilution for optimal results. |
| Immunogen | A synthetic peptide of human PRKC. |
| MW | 37kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959). |
| Tissue specificity | Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta. |
| Posttranslational modification | Phosphorylated by the TGF-beta receptor. |
| Celluar localization | Cytoskeleton;Cytosol;Nucleus;Plasma Membrane; |
| UniPort | Q9NPB6 |
Western blot analysis of extracts of 193T celllines, using PARD6Aantibody|Immunohistochemistryof paraffin-embeddedhuman gastric cancer tissue usingPARD6Aantibody.
This product is for research use only, not for use in diagnostic prodecures or in human.
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