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Rabbit Anti-TNAP1 Polyclonal Antibody#abs133573

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Description

Catalog-specification	Delivery time	USD price
abs133573-100ug	1-2 Weeks	301.0
abs133573-50ug	1-2 Weeks	201.0

Overview
catalog	abs133573
Other names	Tumor necrosis factor alpha induced protein 1, also known as TNFAIP1, is a protein that is induced by the presence of alpha-induced protein 1 and tumor necrosis factor. It is also referred to as endothelial protein BACD2_HUMAN, hBACURD2, or Protein B12. This protein belongs to the BTB/POZ domain-containing adapter family and plays a role in CUL3-mediated degradation of RhoA. TNFAIP1 is an important factor in endothelial function and is involved in various cellular processes.
Source	Rabbit
Specificity	The TNAP1 Antibody is capable of detecting total TNAP1 levels in the body naturally. To create a similar text, the content can be rearranged while still retaining the original meaning.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Sheep;Dog;Horse;
Antigen	TNAP1
Application	The suggested dilution ratios for WB are 1:500 to 1:1000, for IF/ICC are 1:100 to 1:500, and for ELISA (peptide) are 1:20000 to 1:40000. Please meet these recommended dilution ratios to ensure accurate results in your experiments.
Immunogen	A synthesized peptide.
MW	34 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography in the purification process of the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity of the product, it is important to store it at a temperature of -20 °C for a year. You should also avoid any instances of repeated freezing and thawing, as this could impact the quality of the product. It is important to adhere to these guidelines in order to maintain the intended properties of the product.
Storage buffer	This product is Rabbit IgG that comes in phosphate buffered saline with a pH of 7.4. It also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this product at a temperature of -20 °C. Its shelf life is stable for 12 months starting from the date of receipt.
Target
Background	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.
Tissue specificity	By TNF, IL1B/interleukin-1 beta and bacterial lipopolysaccharides (LPS).
Posttranslational modification	Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA.
Celluar localization	Endosome;Nucleus;
UniPort	Q13829

Western blot analysis of extracts from HUVEC cells treated with PMA (125ng/ml, 30mins), and HUVEC cells treated with serum (20%, 30mins), using TNAP1 antibody.

This product is for research use only, not for use in diagnostic prodecures or in human.

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