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Rabbit Anti-TGIF1 Polyclonal Antibody#abs137166

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Description

Catalog-specification	Delivery time	USD price
abs137166-100ug	1-2 Weeks	301.0
abs137166-50ug	1-2 Weeks	201.0

Overview
catalog	abs137166
Other names	The protein known as TGIF1, or TG-interacting factor, is a homeobox protein that plays an important role in cell development and differentiation. It is also known as transforming growth factor-beta-induced factor, or TGFB-induced factor homeobox 1. TGIF1 interacts with the DNA sequence 5'-TG-3', which allows it to regulate gene expression. Research has identified TGIF1 as a key factor in several developmental disorders, including holoprosencephaly type 4 (HPE4). Despite its important functions, the exact mechanisms through which TGIF1 interacts with other proteins and regulatory factors are still being studied. Overall, TGIF1 is an important protein that plays a critical role in regulating gene expression and cell differentiation. Its interactions with other proteins and DNA sequences make it a fascinating subject of study for researchers in a variety of fields, from developmental biology to genetics and beyond.
Source	Rabbit
Specificity	The detection of endogenous levels of total TGIF1 can be achieved using the TGIF1 Antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Pig;Dog;Horse;
Antigen	TGIF1
Application	WB1:10001:3000，/1:1001:500，（ELISA）1:200001:40000。，。
Immunogen	A synthesized peptide derived from human TGIF1.
MW	45 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. This resulted in a highly refined and purified antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve quality, it is recommended that you store the item at a temperature of -20 °C for a duration of one year. It is important to avoid repeated cycles of freezing and thawing.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
Celluar localization	Nucleus;
UniPort	Q15583