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Rabbit Anti-SUMO2 Polyclonal Antibody#abs136544

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Description

Catalog-specification	Delivery time	USD price
abs136544-100ug	1-2 Weeks	301.0
abs136544-50ug	1-2 Weeks	201.0

Overview
catalog	abs136544
Description	This particular gene plays a pivotal role in encoding a protein belonging to the small ubiquitin-like modifier (SUMO) protein family. Its function is akin to that of ubiquitin, as it attaches itself to target proteins during post-translational modification. However, unlike ubiquitin's role in marking proteins for degradation, this protein is involved in a wide array of cellular processes, including nuclear transport, transcriptional regulation, apoptosis, and protein stability. Notably, it remains inactive until the carboxy-terminus's last two amino acids are removed. It is worth mentioning that numerous pseudogenes have been discovered for this gene. Moreover, alternative transcriptional splice variants have been identified, resulting in the creation of different isoforms of the protein.
Other names	Here is a rearranged version of the content: The following are various names for HSMT3, also known as MGC117191: OTTHUMP00000115275, OTTHUMP00000115276, OTTHUMP00000115277, Sentrin 2, Small ubiquitin like modifier 2, Small ubiquitin related modifier 2, small ubiquitin-like modifier 3, small ubiquitin-related modifier 3, SMT3 homolog 1, SMT3 homolog 2, SMT3 suppressor of mif two 3 homolog 1, SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae), SMT3 suppressor of mif two 3 homolog 2, SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae), SMT3 suppressor of mif two 3 homolog 3, SMT3A, SMT3B, SMT3H1, SMT3H2, Sumo2, Sumo3, Ubiquitin like protein SMT3A, and Ubiquitin like protein SMT3B.
Source	Rabbit
Specificity	The total SUMO2 levels in the body can be detected using the SUMO2 Antibody. This antibody is capable of detecting endogenous levels of the entire SUMO2 protein. To generate content closely resembling this statement, one could say: The endogenous levels of total SUMO2 in the body can be identified through the use of the SUMO2 Antibody, which has the ability to detect the entire protein.
Species Reactivity	Human;Mouse;Rat
Antigen	SUMO2/SUMO3
Application	The dilution ratios for WB are 1:500-1:2000, for IHC are 1:50-1:200, and for ELISA(peptide) are 1:20000-1:40000. It is important to note that these ratios represent the recommended dilutions for these specific assays.
Immunogen	A synthesized peptide derived from human SUMO2.
MW	11kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
Tissue specificity	Broadly expressed.
Posttranslational modification	Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4.Cleavage of precursor form by SENP1 or SENP2 is necessary for function.Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitination by the UBE2V1-UBE2N heterodimer.
Celluar localization	Nucleus;
UniPort	P61956