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Rabbit Anti-STAR Polyclonal Antibody#abs135712

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Description

Catalog-specification	Delivery time	USD price
abs135712-100ug	1-2 Weeks	301.0
abs135712-50ug	1-2 Weeks	201.0

Overview
catalog	abs135712
Description	StAR, also known as steroidogenic acute regulatory protein, is crucial in facilitating the transport of cholesterol from the cytoplasmic outer membrane to the inner mitochondrial membrane. This protein plays a key role in cholesterol metabolism and can transform cholesterol into pregnenolone, with an active 28 kDa protein being generated from a 37 kDa precursor. Its predominant expression occurs in the mitochondria of steroid-producing gonadal and adrenal tissue. In cases of autosomal Lipoid Congenital Adrenal Hyperplasia (LCAH), the StAR gene expression can be adversely affected, resulting in defects in the production of cortisol and pregnenolone. Despite extensive research, the exact mechanism of how StAR binds to cholesterol still remains unknown.
Other names	Steroidogenic acute regulatory protein, commonly known as StAR or StAR-related lipid transfer (START) domain-containing protein 1, is a cholesterol trafficker and luteinizing hormone-induced protein. It is primarily found in the mitochondria and plays a crucial role in steroid hormone synthesis. StAR facilitates the transfer of cholesterol into the mitochondria, where it is converted into steroid hormones such as cortisol, estrogen, and testosterone. This mitochondrial steroid acute regulatory protein acts as a key regulator in the production of these hormones, ensuring their availability for various physiological processes. StAR is an essential component of the steroidogenic pathway and is responsible for maintaining hormonal balance and homeostasis. Its vital role in cholesterol trafficking and steroidogenesis highlights the significance of this protein in endocrine function.
Source	Rabbit
Specificity	The STAR Antibody is capable of detecting the total STAR protein at endogenous levels. Hence, it can efficiently identify and measure the presence of STAR in a sample.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	STAR
Application	IHC 1:50-1:200, WB 1:500-1:2000, and ELISA (peptide) 1:20000-1:40000 are the recommended dilution ranges for different assays. It is important to follow these guidelines while conducting experiments to ensure accurate and reliable results.
Immunogen	A synthesized peptide derived from human STAR.
MW	32kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
Tissue specificity	Expressed in gonads, adrenal cortex and kidney.
Celluar localization	Cytosol;Mitochondrion;
UniPort	P49675