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Rabbit Anti-ST Polyclonal Antibody#abs138136

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Description

Catalog-specification	Delivery time	USD price
abs138136-100ug	1-2 Weeks	301.0
abs138136-50ug	1-2 Weeks	201.0

Overview
catalog	abs138136
Other names	The 5-HTT protein, also known as the serotonin transporter, is encoded by the SLC6A4 gene. It is responsible for the uptake of the neurotransmitter serotonin from the synapse, regulating serotonin levels in the brain. Variants in the gene, such as 5-HTTLPR, affect the expression and function of the protein and have been associated with various mental disorders, including depression, anxiety, and OCD. The protein is a target for antidepressant medications, such as selective serotonin reuptake inhibitors (SSRIs), which block the reuptake of serotonin by the transporter, increasing the availability of the neurotransmitter in the brain. It is also studied for its role in mood regulation, emotion processing, and behavior.
Source	Rabbit
Specificity	ST Antibody detects endogenous levels of total ST.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Horse;
Antigen	ST
Application	The recommended dilutions for WB are 1:1000 to 1:3000, for IHC it is 1:50 to 1:200, and for ELISA using peptides, the recommended dilution range is 1:20000 to 1:40000. It is important to follow these dilution guidelines to ensure accurate and reliable results in your experiments. Dilution beyond the recommended range may result in weaker signals or increased background noise.
Immunogen	A synthesized peptide derived from human ST.
MW	70 kDa
Properties
Concentration	1mg/ml
purification	The process of purifying the antiserum involved the use of SulfoLink™ Coupling Resin for peptide affinity chromatography. This highly effective technique ensured that the resulting antiserum was of the highest possible quality and purity, making it ideal for use in a wide range of applications. By carefully isolating and purifying the specific peptides of interest, our team was able to create a highly potent and effective antiserum that is sure to deliver outstanding results. With our focus on quality and attention to detail, you can trust that our antiserum will meet all of your needs and exceed your expectations.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its efficacy, it is recommended to store the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to multiple freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
Tissue specificity	Expressed in platelets (at protein level).
Posttranslational modification	Glycosylated; modification with sialylated N-glycans is a requirement for transporters to associate with each other and to function as homooligomeric forms.Phosphorylation at Thr-276 increases 5-HT uptake and is required for cGMP-mediated SERT regulation. Phosphorylation upon PKC stimulation modifies the SERT distribution and density in the membrane, and diminishes the uptake capacity.
Celluar localization	Cytosol;Endosome;Plasma Membrane;
UniPort	P31645