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Rabbit Anti-SIGMAR1 Polyclonal Antibody#abs136875

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Description

Catalog-specification	Delivery time	USD price
abs136875-100ug	1-2 Weeks	301.0
abs136875-50ug	1-2 Weeks	201.0

Overview
catalog	abs136875
Description	This particular gene is responsible for encoding a receptor protein that interacts with a variety of drugs that are known to induce psychosis, including cocaine and amphetamines. The receptor is essential in the functioning of various tissues associated with the endocrine, immune, and nervous systems. It was formerly thought to be an opioid receptor and was even labeled as such, bearing the name opioid receptor sigma 1 (OPRS1). However, it has now been identified as a non-opioid receptor. Certain mutations in this gene have been found to be associated with juvenile amyotrophic lateral sclerosis 16. The gene also undergoes alternative splicing, resulting in transcripts that encode different isoforms.
Other names	The Sigma-1 receptor, also known as the Aging-associated gene 8 protein or SGMR1_HUMAN, is a type of opioid receptor that is associated with aging. It is also known as the Sigma non-opioid intracellular receptor 1, or Sigmar1 for short. This protein is encoded by the AL024364 gene and may play a role in neuroprotection and cell survival. In addition, it has been suggested that the Sigma-1 receptor may be involved in various diseases, such as Alzheimer's and Parkinson's. The protein is expressed in many tissues throughout the body, including the brain, heart, and liver. It interacts with various compounds, such as cocaine and amphetamines, as well as drugs that are used to treat mental disorders. The Sigma-1 receptor is an intriguing protein with many potential therapeutic applications, and its role in aging and disease continues to be studied.
Source	Rabbit
Specificity	The SIGMAR1 Antibody is capable of detecting total SIGMAR1 at levels that are naturally present within the body. This means that it can accurately identify and measure the protein regardless of its existing concentration. To put it simply, the SIGMAR1 Antibody is a reliable tool for detecting SIGMAR1 within biological samples and can provide valuable insights into various physiological processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	SIGMAR1
Application	The recommended dilutions for western blotting are 1:500-1:2000, while for immunohistochemistry, the suggested dilutions range from 1:50 to 1:200. For ELISA with peptide substrates, the optimal dilutions would be within 1:20000-1:40000. These dilution guidelines will ensure that the target protein or antigen is effectively detected while minimizing background interference. Please note that the dilution ratios may vary depending on the experimental conditions and assay sensitivity.
Immunogen	A synthesized peptide derived from human SIGMAR1.
MW	25kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria (By similarity).
Tissue specificity	Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells. Expressed in alpha-motor neurons (PubMed:23314020).
Celluar localization	Endoplasmic reticulum;Nucleus;Plasma Membrane;
UniPort	Q99720