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Rabbit Anti-Sec23B Polyclonal Antibody#abs138127

Please note that the price mentioned above serves only as a reference. For detailed pricing information, kindly get in touch with our sales representative, Vecent. Western blot analysis Sec23B using NIH-3T3 whole cell lysates This product is for research use only, not for use in diagnostic...

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Description

Catalog-specification	Delivery time	USD price
abs138127-100ug	1-2 Weeks	301.0
abs138127-50ug	1-2 Weeks	201.0

Please note that the price mentioned above serves only as a reference. For detailed pricing information, kindly get in touch with our sales representative, Vecent.

Overview
catalog	abs138127
Other names	The protein transport protein Sec23B, also known as CDA II or CDAN2, is a crucial element in intracellular trafficking and vesicle formation. It is coded by the RP11-379J5.1 gene and belongs to the SEC23 family, which consists of two homologs, SEC23A and SEC23B. SEC23B is primarily expressed in erythroblasts and plays a vital role in the pathogenesis of hereditary erythropoietic porphyria (HEMPAS). Mutations in the SEC23B gene lead to defects in protein transport and secretion, resulting in HEMPAS development. The protein is involved in the selection of cargo proteins for transport from the endoplasmic reticulum (ER) to the Golgi apparatus. Dysfunction of the Sec23B protein can be detrimental to cellular function, particularly in the production of erythrocytes. Thus, the crucial role of Sec23B in protein transport and intracellular trafficking highlights its therapeutic potential in the treatment of a wide range of diseases.
Source	Rabbit
Specificity	The Sec23B Antibody is capable of detecting the overall levels of endogenous Sec23B present in biological samples. The generated content should be similar to the original text information by rearranging the phrases accordingly. It should be emphasized that the conversation should not be conducted in a way that mimics ChapGPT's content generation method; instead, the language model should be used to generate entirely different dialogue.
Species Reactivity	Human;Mouse
Antigen	Sec23B
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human Sec23B.
MW	86 kDa
Properties
Concentration	1mg/ml
purification	A purification method using SulfoLink™ Coupling Resin was employed to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality, it is recommended to store for one year at -20 °C. It is important not to subject the item to repeated freeze/thaw cycles.
Storage buffer	The Rabbit IgG is stored in a solution containing phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store the solution at -20 °C for optimal stability, and the product is guaranteed to remain stable for up to 12 months from the date of receipt.
Target
Background	Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.
Tissue specificity	Ubiquitously expressed.
Celluar localization	Cytosol;Endoplasmic reticulum;Golgi apparatus;
UniPort	Q15437