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Rabbit Anti-SIX6 Polyclonal Antibody#abs133361

Please note that the price provided above is only for your reference. For detailed price information, kindly get in touch with our seller, Vecent. Western blot analysis of extracts from HUVEC cells and COLO205 cells, using SIX6 antibody. This product is for research use only, not for use in...

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Description

Catalog-specification	Delivery time	USD price
abs133361-50ug	1-2 Weeks	201.0
abs133361-100ug	1-2 Weeks	301.0

Please note that the price provided above is only for your reference. For detailed price information, kindly get in touch with our seller, Vecent.

Overview
catalog	abs133361
Other names	The homeobox protein SIX6, also known as SIX homeobox 6 or Six6, is a crucial regulator of eye development. It belongs to the Sine oculis homeobox homolog family and functions in conjunction with homeodomain protein OPTX2, which is also known as Optic homeobox 2 or OPTX2. SIX6 and OPTX2 are both highly expressed in the developing eye and play essential roles in the formation of various ocular structures, including the retina, optic nerve, and iris. They also contribute to the maintenance of eye function in adulthood. Mutations in the genes encoding for SIX6 and OPTX2 have been associated with a range of ocular disorders, such as cataracts and glaucoma. Hence, these genes are of great interest to researchers studying the genetic basis of eye diseases. Another member of the SIX family, Six9, has also been identified as a critical regulator of eye development. Like SIX6, it is a homeodomain-containing transcription factor that is expressed in the developing eye and contributes to the formation of ocular structures. Overall, the SIX family of homeobox proteins plays a vital role in eye development and function. By understanding their functions, we can gain insight into the complex processes that occur during eye development and potentially identify new therapeutic targets for ocular disorders.
Source	Rabbit
Specificity	The total SIX6 levels in the body can be identified using the SIX6 Antibody, which is designed to specifically detect the endogenous levels of SIX6.
Species Reactivity	Human;Mouse;Rat
Antigen	SIX6
Application	For Western Blotting, an optimal dilution is 1:500 to 1:1000, while for Immunofluorescence/Immunocytochemistry, a dilution of 1:100 to 1:500 is recommended. When utilizing ELISA with peptide, a dilution of 1:20000 to 1:40000 works best. To generate unique content based on the same information, it is advisable to combine and rephrase the details in a different manner to provide a refreshed perspective on the original data.
Immunogen	A synthesized peptide.
MW	28 KD
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was employed in the peptide affinity chromatography process to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended that the product be kept at a temperature of -20 °C for a period of one year. Care must be taken to avoid any instances of repeated freeze/thaw cycles, as this can have a negative impact on the product's quality. Following these guidelines will help to maintain the potency and effectiveness of the product over an extended period of time.
Storage buffer	The storage conditions for Rabbit IgG are as follows: it should be stored at -20°C in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The stability of the IgG is guaranteed for a period of 12 months from the date of receipt.
Target
Background	May be involved in eye development.
Tissue specificity	Expressed in the developing and adult retina. Also expressed in the hypothalamic and the pituitary regions.
Celluar localization	Nucleus;
UniPort	O95475