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Rabbit Anti-SOX10 Polyclonal Antibody#abs137486

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Description

Catalog-specification	Delivery time	USD price
abs137486-100ug	1-2 Weeks	301.0
abs137486-50ug	1-2 Weeks	201.0

Overview
catalog	abs137486
Other names	SRY box containing gene 10, also known as SOX10 or SRY (sex determining region Y) box 10, is a dominant gene linked to a human disorder called Dominant megacolon. The human homolog of the mouse gene MGC15649, SOX10 plays a crucial role as a transcription factor. It is involved in the regulation of various genetic processes and is associated with conditions like WS2E, WS4, and WS4C. SOX10_HUMAN, the human variant of this gene, belongs to the SRY-related HMG box gene family. Its function as a transcription factor contributes to the development and maintenance of normal cellular processes.
Source	Rabbit
Specificity	The SOX10 Antibody is capable of detecting the total endogenous levels of SOX10 protein. The content can be rephrased as, the antibody against SOX10 is designed to identify and measure the entirety of SOX10 protein present in the organism, at its natural levels.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine
Antigen	SOX10
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human SOX10.
MW	60 kDa
Properties
Concentration	1mg/ml
purification	The purification of the antiserum was done via SulfoLink™ Coupling Resin peptide affinity chromatography. This method ensured a high degree of purity in the final product.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure stability, the product should be stored for one year at -20 °C. It is important to avoid subjecting it to repeated freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program.
Tissue specificity	Expressed in fetal brain and in adult brain, heart, small intestine and colon.
Celluar localization	Mitochondrion;Nucleus;
UniPort	P56693