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Rabbit Anti-CASQ2 Polyclonal Antibody#abs137485

Description

Catalog-specification	Delivery time	USD price
abs137485-100ug	1-2 Weeks	301.0
abs137485-50ug	1-2 Weeks	201.0

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Overview
catalog	abs137485
Other names	Calsequestrin 2, also known as CASQ2 or cardiac calsequestrin 2, is a protein that plays a key role in the regulation of calcium in cardiac muscle cells. This protein is found in the fast twitch cardiac muscle and is an isoform of calsequestrin. Some other names for this protein include cardCSQ, ESTM52, FLJ26321, and PDIB2. The gene that codes for calsequestrin 2 is located on chromosome 1 in humans. Mutations in this gene have been associated with arrhythmogenic right ventricular cardiomyopathy, a heart disease characterized by abnormal heart rhythms and other cardiac abnormalities. Understanding the function and regulation of calsequestrin 2 is an important area of research in the field of cardiovascular medicine.
Source	Rabbit
Specificity	CASQ2 AntibodyCASQ2。，。，ChapGPT，。
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Sheep;Dog;Horse;Bovine;
Antigen	CASQ2
Application	The recommended dilutions for WB are between 1:1000 and 1:3000, for IHC it's 1:200, and for ELISA using peptide it's 1:20000 to 1:40000. It's important to follow these dilution recommendations to ensure the best results when performing these assays. When dilutions are not accurate, it can lead to false positives or false negatives, which can hinder the accuracy and reliability of the data obtained. So, take note of the recommended dilutions and use them accordingly.
Immunogen	A synthesized peptide derived from human CASQ2.
MW	46 kDa
Properties
Concentration	1mg/ml
purification	We utilized SulfoLink™ Coupling Resin for peptide affinity chromatography in order to purify the antiserum. Let me rearrange this information and generate a highly similar content for you.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain optimal conditions, it is recommended to store the item at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to multiple freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca2+ ions. Regulates the release of lumenal Ca2+ via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
Posttranslational modification	Phosphorylation in the C-terminus, probably by CK2, moderately increases calcium buffering capacity.N-glycosylated.
Celluar localization	Endoplasmic reticulum;
UniPort	O14958