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Rabbit Anti-ROBLD3 Polyclonal Antibody#abs138541

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Description

Catalog-specification	Delivery time	USD price
abs138541-100ug	1-2 Weeks	301.0
abs138541-50ug	1-2 Weeks	201.0

Overview
catalog	abs138541
Other names	LAMTOR2, also known as endosomal adaptor protein p14, is an important protein involved in endosomal and lysosomal function. It interacts with MAPK and MTOR, activating these signaling pathways. Its role as a late endosomal/lysosomal adaptor and MAPK and MTOR activator is crucial for various cellular processes. In addition, it is a binding partner of the protein Mp1, which is associated with late endosomal/lysosomal structures. LAMTOR2, also referred to as MAPBPIP or MAPKSP1 adaptor protein, plays a significant role in mediating interactions between mitogen-activated proteins and their binding partners. It is a key component of the Ragulator complex, aiding in protein transport and localization to specific cellular compartments. LAMTOR2 is also known as Roadblock domain containing protein 3 or ROBLD 3. Its diverse functions highlight the importance of this protein in cellular processes and make it a subject of interest for further research.
Source	Rabbit
Specificity	Total ROBLD3 levels can be detected using ROBLD3 Antibody, which can specifically recognize endogenous ROBLD3.
Species Reactivity	Human;Mouse
Antigen	ROBLD3
Application	WB (western blotting)1:1000-3000。(IHC)1:200。(ELISA)1:20000-1:40000。，。
Immunogen	A synthesized peptide derived from human ROBLD3.
MW	14 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we were able to purify the antiserum via peptide affinity chromatography. This process allowed for the separation and isolation of the specific peptides present in the antiserum, resulting in a highly purified final product.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its stability, the product should be stored at -20 °C for a duration of one year. It is important to prevent any freeze/thaw cycles from occurring repeatedly.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
Celluar localization	Endosome;Extracellular region or secreted;Lysosome;Plasma Membrane;
UniPort	Q9Y2Q5