Rabbit Anti-CCKBR Polyclonal Antibody#abs135163
Please note that the price mentioned is for your reference only and for detailed pricing information, kindly get in touch with our seller, Vecent. It is important to reach out to Vecent to ensure that you have the correct and accurate pricing information. This product is for research use only,...
Description
| Catalog-specification | Delivery time | USD price |
abs135163-100ug | 1-2 Weeks | 301.0 |
abs135163-50ug | 1-2 Weeks | 201.0 |
Please note that the price mentioned is for your reference only and for detailed pricing information, kindly get in touch with our seller, Vecent. It is important to reach out to Vecent to ensure that you have the correct and accurate pricing information.
| Overview | |
catalog | abs135163 |
| Other names | The CCK B receptor, also known as CCK BR or CCK-BR, CCK2 R, CCK2 receptor, CCK2-R, CCKB, CCKB receptor, CCKBR, CCKR Type B, CCKRB, Cholecystokinin 2 receptor, Cholecystokinin B receptor, Cholecystokinin-2 receptor, Cholecystokinin2 receptor, CholecystokininB receptor, GASR, GASR_HUMAN, Gastrin receptor, or Gastrin/cholecystokinin type B receptor is a key player in the signaling pathway of cholecystokinin. This receptor is involved in various physiological processes such as gastric acid secretion, smooth muscle contraction, and satiety. The CCK B receptor is abundantly expressed in the brain and gastrointestinal tract, playing a crucial role in the regulation of food intake and energy homeostasis. Understanding the function and regulation of the CCK B receptor can provide valuable insights into the pathogenesis of various diseases related to appetite control and gastrointestinal disorders. Research on this receptor has highlighted its potential as a therapeutic target for obesity, gastrointestinal motility disorders, and psychiatric disorders. Overall, the CCK B receptor, with its wide distribution and diverse functions, holds promise for advancements in various fields of medicine and biology. The continued investigation of this receptor will contribute to a deeper understanding of its mechanisms and potential therapeutic applications. |
| Source | Rabbit |
| Specificity | The antibody, CCKBR Antibody, is specifically designed to recognize and bind to the levels of total CCKBR that naturally occur within an organism. Its main purpose is to detect and measure the endogenous levels of this protein. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | CCKBR |
| Application | 1:5001:1000。，1:1001:500。(ELISA)，1:200001:40000。。 |
| Immunogen | A synthesized peptide. |
| MW | 48 KD |
| Properties | |
Concentration | 1mg/ml |
| purification | The purification process for the antiserum involved employing SulfoLink™ Coupling Resin in peptide affinity chromatography. This ensured that the antiserum was thoroughly purified and ready for use in various applications. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To maintain its stability, store the item at -20 °C for a duration of one year and ensure it is not subjected to repeated freeze/thaw cycles. It is essential to follow these guidelines strictly. |
| Storage buffer | The rabbit IgG is stored in a solution of phosphate buffered saline (pH 7.4), 150mM NaCl, 0.02% sodium azide, and 50% glycerol at a temperature of -20 °C. It remains stable for a period of 12 months from the date of receipt. |
Target | |
Background | Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Tissue specificity | Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo. |
| Celluar localization | Plasma Membrane; |
| UniPort | P32239 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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