Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-RASA1 Polyclonal Antibody#abs133024

Please note that the mentioned price is for reference only. For detailed pricing, kindly get in touch with our seller Vecent. It is important to generate a unique and distinct content from the given information without relying on ChapGPT dialogue generation method. Let's communicate using...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs133024-50ug	1-2 Weeks	201.0
abs133024-100ug	1-2 Weeks	301.0

Overview
catalog	abs133024
Description	The Ras-cyclic AMP pathway is regulated by an inhibitory factor that is capable of stimulating the GTPase of normal Ras p21, but not oncogenic forms of this protein. This information suggests that the inhibitory factor plays a critical role in maintaining the proper balance of Ras signaling within cells. By restricting the activity of normal Ras p21, the inhibitory factor helps to prevent excessive activation of downstream pathways that could lead to uncontrolled cell growth and proliferation. Through further research, scientists hope to gain a better understanding of the mechanisms by which the inhibitory factor operates, and how it might be leveraged to develop new treatments for diseases such as cancer and diabetes.
Other names	Ras GTPase-activating protein 1, also known as RASA1 or p120GAP, is a GTPase activating protein that plays a crucial role in regulating cellular signaling pathways. It helps to effectively turn off the activity of Ras protein, which is involved in numerous cellular processes, including cell growth and differentiation. Mutations in RASA1 have been linked to several genetic disorders, including neurofibromatosis type 1 and Noonan syndrome. The protein is also referred to as CM AVM, CMAVM, DKFZp434N071, GAP, GTPase-activating protein, OTTHUMP00000222390, OTTHUMP00000222391, OTTHUMP00000222392, OTTHUMP00000222393, p120RASGAP, PKWS, Ras p21 protein activator, and triphosphatase activating protein. Through its regulatory activity, RASA1 helps to maintain normal cellular function and prevent the development of disease.
Source	Rabbit
Specificity	The total RASA1 can be precisely identified using RASA1 antibody, which has the ability to detect the natural levels of RASA1 within the body. By rearranging the information provided, a highly similar content can be generated.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep;Horse;
Antigen	RASA1
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	110 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized to perform peptide affinity chromatography in order to purify the antiserum. A highly similar content can be generated by rearranging the sentence structure and emphasizing the key points of the original text.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1.
Tissue specificity	In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level).
Posttranslational modification	The N-terminus is blocked.Phosphorylated by SRC and LCK. The phosphorylation SRC inhibits its ability to stimulate the Ras-GTPase activity, whereas phosphorylation by LCK does not display any effect on stimulation activity.
Celluar localization	Cytosol;Plasma Membrane;
UniPort	P20936