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Rabbit Anti-RAD51L1 Polyclonal Antibody#abs140708

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Description

Catalog-specification	Delivery time	USD price
abs140708-100ug	1-2 Weeks	301.0
abs140708-50ug	1-2 Weeks	201.0

Overview
catalog	abs140708
Other names	RAD51 homolog 2, also known as hREC2, MGC34245, OTTHUMP00000212251, OTTHUMP00000212253, OTTHUMP00000212254, OTTHUMP00000212255, R51H2, RA51B_HUMAN, RAD51 homolog B (S. cerevisiae), RAD51 homolog B, RAD51 like 1, RAD51 like protein 1, RAD51-like protein 1, Rad51B, RAD51L1, REC2, RecA like protein, and Recombination repair protein is a crucial DNA repair protein. It plays a significant role in maintaining the integrity of the genome by repairing damaged DNA. The protein is highly conserved and shares similarity with the RAD51 protein in Saccharomyces cerevisiae. RAD51 homolog 2, commonly referred to as hREC2, is involved in homologous recombination, a vital DNA repair mechanism. It is essential for repairing double-strand DNA breaks and maintaining genomic stability. The protein is encoded by the gene RAD51B and is known for its conserved structure and function across various species. Also designated as MGC34245, OTTHUMP00000212251, OTTHUMP00000212253, OTTHUMP00000212254, OTTHUMP00000212255, R51H2, RA51B_HUMAN, RAD51 homolog B (S. cerevisiae), RAD51 homolog B, RAD51 like 1, RAD51 like protein 1, RAD51-like protein 1, Rad51B, RAD51L1, REC2, RecA like protein, and Recombination repair protein, this versatile protein plays a crucial role in protecting the genome from various forms of DNA damage. Through its interaction with other RAD51-like proteins, RAD51 homolog 2 facilitates the formation of RAD51 nucleoprotein filaments, which are essential for homologous DNA pairing and strand exchange during DNA repair processes. Its involvement in DNA repair mechanisms highlights its significance in maintaining genome stability and preventing harmful mutations. In summary, RAD51 homolog 2 (hREC2) is an important DNA repair protein that plays a vital role in maintaining genomic integrity through its involvement in homologous recombination. It is encoded by the RAD51B gene and shares structural and functional similarity with the RAD51 protein in S. cerevisiae. By promoting RAD51 nucleoprotein filament formation, RAD51 homolog 2 ensures efficient DNA repair and safeguards the genome from potential damage.
Source	Rabbit
Specificity	Endogenous levels of total RAD51L1 can be detected with the RAD51L1 Antibody.
Species Reactivity	Human;Mouse;Monkey
Antigen	RAD51L1
Application	For Western blotting, the recommended dilution range is between 1:500 and 1:1000. When it comes to immunohistochemistry, a dilution range of 1:50 to 1:200 is recommended for optimal results. For immunofluorescence and immunocytochemistry, a dilution range of 1:100 to 1:500 is suggested. If you are performing an ELISA assay using a peptide, the recommended dilution range is between 1:20000 and 1:40000. By following these recommended dilution ranges, you can ensure that your experiment yields accurate and reproducible results.
Immunogen	A synthesized peptide.
MW	45 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the purification of the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	The recommended storage for one year is at -20 °C. It is important to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	This product contains Rabbit IgG in high-quality phosphate buffered saline at a pH of 7.4, with 150 millimoles of NaCl and 0.02% sodium azide for stability. It is supplied with 50% glycerol to maximize storage life when kept at -20°C. Shelf life is guaranteed for up to 12 months from the receipt date.
Target
Background	Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway.
Tissue specificity	Expressed in a wide range of tissues.
Posttranslational modification	Phosphorylated on tyrosine residues by BCR-ALB.
Celluar localization	Nucleus;
UniPort	O15315