Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-PSME1 Polyclonal Antibody#abs136810

Please note that the price provided is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent. Please be advised that the content generated will be in a significantly different format, as it will not be based on a conversation style like ChapGPT....

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs136810-100ug	1-2 Weeks	301.0
abs136810-50ug	1-2 Weeks	201.0

Overview
catalog	abs136810
Description	The 26S proteasome is a complex multicatalytic proteinase structure that comprises two distinct components, the 20S core and the 19S regulator. The former is made up of four rings consisting of 28 subunits, comprising 7 alpha and 7 beta subunits each. The latter, on the other hand, is composed of a base with 6 ATPase subunits and 2 non-ATPase subunits, and a lid that may have up to 10 non-ATPase subunits. Proteasomes are present in high concentrations in various eukaryotic cells and engage in an ATP/ubiquitin-mediated peptide cleavage mechanism. This non-lysosomal pathway is crucial for many cellular processes. One type of altered proteasome that performs a vital function in processing class I MHC peptides is the immunoproteasome. This variant includes an alternate regulator, known as the 11S regulator or PA28, in place of the 19S regulator. The 11S regulator has three subunits, namely alpha, beta, and gamma, with the alpha subunit documented to be a contributor to gamma-interferon induction. The alpha subunit combines with the other subunits to produce a heterohexameric ring. Various transcript versions may arise due to alternative splicing.
Other names	Alpha subunit of the 11S regulator complex; Subunit alpha of the 11S regulator complex; Activator subunit of 29 kD MCP; Subunit of 29kD MCP activator; Subunit 1 of the activator of multicatalytic protease; IFI5111; IGUP I-5111; Interferon gamma IEF SSP 5111; Interferon gamma inducible protein 5111; Up-regulated protein I-5111 by interferon gamma; Protein MGC8628; PA28a; PA28alpha; Subunit 1 of the proteasome activator (PA28 alpha); Alpha subunit of the proteasome activator 28; Complex subunit 1 of the proteasome activator; Subunit 1 of the proteasome activator; PSME1; PSME1_HUMAN; REG-alpha; REGalpha. Please rearrange the given information to generate a highly similar content, ensuring that the generated content is based on the original text information.
Source	Rabbit
Specificity	The PSME1 Antibody is able to recognize the total PSME1 present in the body at any given time. This means that it can detect both the naturally occurring levels of PSME1 as well as any changes that might occur over time. If you are looking to monitor the levels of PSME1 in a particular sample, then this antibody can be a valuable tool in your research. By detecting the total PSME1, you can gain insight into the underlying processes and functions of this essential protein.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Bovine;Sheep;Rabbit;
Antigen	PSME1
Application	WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human PSME1.
MW	28kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
Tissue specificity	By IFNG/IFN-gamma.
Celluar localization	Cytosol;Extracellular region or secreted;Nucleus;
UniPort	Q06323