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Rabbit Anti-SDCBP Polyclonal Antibody#abs136812

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Description

Catalog-specification	Delivery time	USD price
abs136812-100ug	1-2 Weeks	301.0
abs136812-50ug	1-2 Weeks	201.0

Overview
catalog	abs136812
Description	Syntenin is a protein that was originally discovered as a connecting molecule between syndecan-mediated signals and the cytoskeleton. It is comprised of multiple PDZ domains, which are capable of binding to the cytoplasmic C-terminal domains of various transmembrane proteins. This protein plays a crucial role in the organization of cytoskeletal-membrane interactions, cell adhesion, protein trafficking, and the regulation of transcription factors. Syntenin is predominantly located at membrane-associated adherens junctions and focal adhesions, but can also be found in localized regions within the endoplasmic reticulum and nucleus. As a result of alternative splicing, there are multiple transcript variants that encode for distinct isoforms of the protein.
Other names	MDA-9, also known as melanoma differentiation-associated protein 9, is a crucial molecule involved in various cellular processes. It is alternatively referred to as Pro-TGF-alpha cytoplasmic domain-interacting protein 18, Scaffold protein Pbp1, SDCB1_HUMAN, SDCBP, ST1, SYCL, Syndecan binding protein (syntenin), Syndecan binding protein 1, Syndecan-binding protein 1, Syntenin 1, Syntenin-1, or TACIP18. MDA-9 plays a significant role in melanoma differentiation and has been extensively studied in this context. Additionally, it interacts with the cytoplasmic domain of Pro-TGF-alpha, leading to the modulation of various signaling pathways. Moreover, MDA-9 acts as a scaffold protein and is involved in the regulation of cellular processes. SDCBP, another name for MDA-9, stands for Syndecan binding protein. This protein plays a crucial role in the interaction between syndecans and other proteins. Syndecans are transmembrane proteoglycans that participate in cell adhesion and signaling. SDCBP, also referred to as syntenin or Syndecan-binding protein 1, acts as a mediator in these interactions and modulates various cellular functions. Overall, MDA-9 or SDCBP is a versatile protein involved in multiple cellular processes, including melanoma differentiation, cytoplasmic domain interaction, scaffold protein function, and syndecan binding. Its diverse roles highlight its significance in various biological contexts.
Source	Rabbit
Specificity	The SDCBP Antibody is capable of detecting total SDCBP present within the body. This means it is capable of identifying natural or endogenous levels of the protein.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Xenopus;Dog;Horse
Antigen	SDCBP
Application	IHC 1:50-1:200, WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000. It is important to note that the provided information presents a range of dilutions for each technique. For Western Blot (WB), the recommended dilutions range from 1:500 to 1:2000. When performing Immunohistochemistry (IHC), it is commonly advised to dilute the primary antibody within the range of 1:50 to 1:200. On the other hand, for ELISA using peptide as the target molecule, the suggested dilution range for the primary antibody is 1:20000 to 1:40000.
Immunogen	A synthesized peptide derived from human SDCBP.
MW	32kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).
Tissue specificity	Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.
Posttranslational modification	Phosphorylated on tyrosine residues.
Celluar localization	Cytoskeleton;Cytosol;Endoplasmic reticulum;Extracellular region or secreted;Lysosome;Nucleus;Plasma Membrane;
UniPort	O00560