Rabbit Anti-PDCD10 Polyclonal Antibody#abs136600
Please note that the price mentioned above is only for your reference and may not be accurate. If you would like to get the exact cost for the product you are interested in, please contact our seller, Vecent. They will be able to provide you with all the necessary details regarding pricing and...
Description
| Catalog-specification | Delivery time | USD price |
abs136600-100ug | 1-2 Weeks | 301.0 |
abs136600-50ug | 1-2 Weeks | 201.0 |
Please note that the price mentioned above is only for your reference and may not be accurate. If you would like to get the exact cost for the product you are interested in, please contact our seller, Vecent. They will be able to provide you with all the necessary details regarding pricing and other relevant information. So, don't hesitate to reach out to them for any queries you may have.
| Overview | |
catalog | abs136600 |
Description | The protein produced by this gene is highly conserved throughout evolution and plays a crucial role in cell apoptosis. It interacts with a serine/threonine protein kinase called MST4 to regulate the extracellular signal-regulated kinase (ERK) pathway. Additionally, it is phosphorylated by serine/threonine kinase 25 and is involved in a signaling pathway that is vital for vascular development. This gene has been associated with mutations that lead to cerebral cavernous malformations, a condition characterized by abnormal blood vessels in the brain. These malformations often result in seizures and cerebral hemorrhages. Interestingly, there are multiple variants of the gene, but they all encode the same protein, suggesting functional similarities among these variants. |
| Other names | Programmed cell death protein 10, also known as PDCD10 or apoptosis-related protein 15, plays a crucial role in the regulation of cell death. It is encoded by the PDCD10 gene and is associated with cerebral cavernous malformations (CCM3). Additionally, it is referred to as TF-1 cell apoptosis-related protein 15 or TFAR15. MGC1212 and MGC24477 are alternative names for this protein. PDCD10, a member of the apoptosis-related protein family, is involved in the apoptotic pathway and has been implicated in various cellular processes. Its function extends beyond apoptosis to include cell proliferation, cell migration, and angiogenesis. CCM3, the cerebral cavernous malformations 3 protein, is of particular interest due to its association with the development of cerebral cavernous malformations (CCMs). CCMs are vascular abnormalities that can cause seizures, hemorrhages, and focal neurological deficits. Understanding the role of PDCD10/CCM3 is crucial in unraveling the mechanisms underlying programmed cell death and the pathogenesis of cerebral cavernous malformations. Further research on this protein may lead to potential therapeutic interventions for diseases associated with abnormal cell death and vascular anomalies. |
| Source | Rabbit |
| Specificity | The PDCD10 Antibody is capable of detecting total PDCD10 at its endogenous levels in the body. This means that it can identify and measure PDCD10 protein levels that occur naturally within the body. To put it simply, the antibody has the ability to recognize and bind to PDCD10, enabling researchers to study its expression and function in various biological processes. Such information can be invaluable in understanding the role that PDCD10 plays in the body and its potential implications in diseases or disorders. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Xenopus;Rabbit;Pig;Sheep;Horse;Bovine;Chicken |
| Antigen | PDCD10 |
| Application | The suggested dilutions for WB are 1:500-1:1000, for IHC are 1:50-1:100, for IF/ICC are 1:100-1:500, and for ELISA (peptide) are 1:20000-1:40000. It is important to follow these dilutions to ensure accurate and reliable results. By rearranging the original content, we can present the dilutions as follows: The recommended dilutions for Western Blot (WB) range from 1:500 to 1:1000. For Immunohistochemistry (IHC), the suggested dilutions are 1:50-1:100. In the case of Immunofluorescence (IF) or Immunocytochemistry (ICC), the suitable dilutions range from 1:100 to 1:500. For Enzyme-Linked Immunosorbent Assay (ELISA) using peptides, the suggested dilutions are 1:20000-1:40000. These dilutions are crucial for obtaining accurate and reliable results in these techniques. |
| Immunogen | Fusion protein of human PDCD10. |
| MW | 25kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006). Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed:27807006). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). |
| Tissue specificity | Ubiquitous. |
| Celluar localization | Cytosol;Extracellular region or secreted;Golgi apparatus;Plasma Membrane; |
| UniPort | Q9BUL8 |
Western blot analysis of extracts of various celllines, using PDCD10antibody|Immunohistochemistry of paraffin-embeddedhuman renal cancer tissue using PDCD10antibody.
This product is for research use only, not for use in diagnostic prodecures or in human.
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