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Rabbit Anti-PCM1 Polyclonal Antibody#abs136976

Description

Catalog-specification	Delivery time	USD price
abs136976-100ug	1-2 Weeks	301.0
abs136976-50ug	1-2 Weeks	201.0

Please note that the price mentioned here is for reference purposes only, and for detailed pricing information, please get in touch with our sales representative, Vecent. It is important to understand that the information shared above is only a rough estimate, and to get an accurate quote, you must consult our expert team. Don't rely solely on the price mentioned here; reach out to us for more information and get a customized quote that suits your specific needs.

Overview
catalog	abs136976
Description	The function of this gene product is to form part of the centriolar satellites, which are small granules surrounding the centrosomes. Experiments have shown that this protein is vital in correctly localizing various proteins in the centrosome and anchoring microtubules to it. Abnormalities in this gene have been linked to several types of cancer, such as papillary thyroid carcinoma and different hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma.
Other names	Pericentriolar material 1, also known as PCM-1 or PCM1, is a protein encoded by the PCM1_HUMAN gene. It is closely associated with the pericentriolar material and plays a significant role in various cellular processes. PCM-1 is essential for the proper organization and function of the centrosome, a crucial component of the cell's microtubule-organizing center. It is involved in the regulation of cell division, cell motility, and cellular signaling pathways. The PCM1 protein, encoded by the PTC4 gene, is highly conserved among species and has been extensively studied in the context of its role in centrosome biology. Understanding the functions of PCM-1 can provide valuable insights into the regulation of cellular processes and the development of novel therapeutic approaches for diseases associated with centrosome dysfunction.
Source	Rabbit
Specificity	The endogenous levels of total PCM1 can be detected using the PCM1 antibody. A highly similar content can be generated by rearranging the above information as follows: Total PCM1 levels in the body can be accurately identified by utilizing the PCM1 antibody, which is capable of detecting the endogenous levels of this protein.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Horse;Bovine;
Antigen	PCM1
Application	The recommended dilution ranges for using this antibody in Western Blot (WB) are 1:500-1:2000 while for Immunohistochemistry (IHC) the recommended dilution ranges are 1:50-1:200. If you are planning to use this antibody in ELISA(peptide), then the recommended dilution range is 1:20000-1:40000. Please note that these are just guidelines for dilution and it is recommended to optimize the dilution of the antibody depending on the experimental conditions and the target protein being detected.
Immunogen	A synthesized peptide derived from human PCM1.
MW	228kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. It was ensured that the resulting content was highly similar to the original text information.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Involved in the biogenesis of cilia.
Tissue specificity	Expressed in blood, bone marrow, breast, lymph node, ovary and thyroid.
Posttranslational modification	Ubiquitinated. Undergoes monoubiquitination catalyzed by the E3 ubiquitin-protein ligase MIB1 in proliferating cells, preventing cilia formation. Monoubiquitination by MIB1 is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, resulting in cilia formation initiation.
Celluar localization	Cytoskeleton;Cytosol;Nucleus;
UniPort	Q15154