Rabbit Anti-NCOA1 Polyclonal Antibody#abs133027
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Description
| Catalog-specification | Delivery time | USD price |
abs133027-50ug | 1-2 Weeks | 201.0 |
abs133027-100ug | 1-2 Weeks | 301.0 |
Please note that the price provided is solely for your reference and for the detailed price, kindly reach out to our seller, Vecent. It is essential to ensure that the generated content is based on the original text information, and we request you to avoid using the ChapGPT language generation method. Therefore, please consider using a different language model to generate entirely new and distinct content.
| Overview | |
catalog | abs133027 |
Description | This coactivator is a crucial player in the transcriptional activation of various nuclear receptors, including those for steroids, retinoids, thyroid hormone, and prostanoids. It binds directly to these receptors and stimulates their transcriptional activities in a hormone-dependent manner. In addition, it can also interact with transcription factors like STAT3, STAT5A, STAT5B, and STAT6, thereby facilitating their coactivation. The coactivator exhibits histone acetyltransferase activity on H3 and H4, although its functional significance in this context remains uncertain. By participating in both chromatin remodeling and recruitment of general transcription factors, it plays a critical role in assembling multisubunit coactivator complexes that can modify chromatin architecture. Notably, this coactivator is required along with NCOA2 to regulate energy balance between white and brown adipose tissues, and it is essential for mediating responses to steroid hormones. Among its isoforms, isoform 2 stands out for its heightened transactivation activity in response to thyroid hormone compared to isoform 1 and isoform 3. |
| Other names | bHLHe74 is a protein known as Class E basic helix-loop-helix protein 74. It is also referred to as F SRC 1, Hin 2 protein, MGC129719, MGC129720, mNRC 1, NCoA 1, NCoA-1, Ncoa1, NCOA1_HUMAN, Nuclear receptor coactivator 1, Nuclear receptor coactivator protein 1, NY REN 52 antigen, Protein Hin 2, Renal carcinoma antigen NY REN 52, Renal carcinoma antigen NY-REN-52, RIP 160, RIP160, SRC 1, SRC-1, or Steroid receptor coactivator 1. These names represent the various ways this protein is identified or referred to in scientific literature and research. The primary function of bHLHe74 is to act as a coactivator for nuclear receptors, specifically those involved in transcriptional regulation of genes. It interacts with these receptors to enhance their activity, leading to increased gene expression. This protein is particularly associated with renal carcinoma and has been identified as a potential antigen for diagnostic purposes. In summary, bHLHe74, or Class E basic helix-loop-helix protein 74, is a versatile coactivator protein involved in the modulation of gene expression. It plays a crucial role in the regulation of nuclear receptors and has been associated with renal carcinoma. Its identification under various names reflects its significance in different research contexts. |
| Source | Rabbit |
| Specificity | The NCOA1 antibody is capable of identifying total NCOA1 levels that occur naturally within the body. To create similar content, the text could be rephrased to say that the use of the NCOA1 antibody allows for the detection of endogenous total NCOA1 levels. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | NCOA1 |
| Application | WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000 |
| Immunogen | A synthesized peptide. |
| MW | 200 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Target | |
Background | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. |
| Tissue specificity | Widely expressed. |
| Posttranslational modification | Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein.Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites. |
| Celluar localization | Cytosol;Nucleus;Plasma Membrane; |
| UniPort | Q15788 |
Western blot analysis of NCOA1 expression in KAT13A / SRC1 transfected 293 cell line lysate;,The lane on the left is treated with the antigen-specific peptide.
This product is for research use only, not for use in diagnostic prodecures or in human.
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