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Rabbit Anti-RASA2 Polyclonal Antibody#abs133026

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Description

Catalog-specification	Delivery time	USD price
abs133026-100ug	1-2 Weeks	301.0
abs133026-50ug	1-2 Weeks	201.0

Overview
catalog	abs133026
Description	A protein that plays a role in regulating the Ras-cyclic AMP pathway is known as an inhibitory regulator. It specifically interacts with inositol tetrakisphosphate (IP4), forming a complex that modulates the pathway's activity. By binding IP4, this regulatory protein is able to exert its inhibitory effect on the Ras-cyclic AMP pathway.
Other names	Ras GTPase activating protein 2, also known as GAP1m, is a crucial protein involved in the regulation of RAS GTPase activity. It plays a pivotal role in the control of cellular signaling pathways. Additionally, it is referred to as RAS p21 protein activator 2 or Rasa2 in scientific literature. The human version of this protein is encoded by the RASA2 gene. Understanding the function and mechanism of RASA2 can provide valuable insights into various biological processes and diseases.
Source	Rabbit
Specificity	The detection of endogenous levels of total RASA2 is possible using the RASA2 antibody. Please rearrange the provided information to generate highly similar content.
Species Reactivity	Human;Mouse;Rat
Antigen	RASA2
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography with SulfoLink™ Coupling Resin was employed to purify the antiserum. The process ensured effective purification, maintaining the original text information.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the material, it is recommended to keep it in a freezer at a temperature of -20 °C for a year. Ensure that the material is not subjected to frequent freeze/thaw cycles. Avoiding repeated freezing and thawing will ensure better preservation.
Storage buffer	The solution contains Rabbit IgG in a buffer of phosphate saline at pH 7.4 with 150mM of sodium chloride, 0.02% sodium azide and 50% glycerol for stability.
Target
Background	The Ras-cyclic AMP pathway is tightly regulated by an inhibitory regulator that is known to bind inositol tetrakisphosphate (IP4). This binding plays a crucial role in controlling the activity of the pathway. By forming a complex with IP4, the inhibitory regulator effectively modulates the signaling cascade, ensuring precise regulation and preventing excessive activation of downstream components. The interaction between the regulator and IP4 facilitates intricate signaling cross-talk, offering a means to fine-tune cellular responses. Understanding the dynamics of this inhibitory regulation adds valuable insights into the intricate mechanisms underlying the Ras-cyclic AMP pathway.
Celluar localization	Cytosol;Plasma Membrane;
UniPort	Q15283