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Rabbit Anti-Pax-6 Polyclonal Antibody#abs137085

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Description

Catalog-specification	Delivery time	USD price
abs137085-100ug	1-2 Weeks	301.0
abs137085-50ug	1-2 Weeks	201.0

Overview
catalog	abs137085
Other names	PAX6, also known as Aniridia type II protein or Aniridia 2, is a gene that plays a crucial role in the development of various tissues in the body. It is located on chromosome 11 and is associated with several conditions, including aniridia keratitis and Wilms tumor. The protein encoded by the PAX6 gene is involved in the formation of the eye and other structures derived from the neuroectoderm. It acts as a transcription factor, regulating the expression of numerous genes involved in eye development. Mutations in the PAX6 gene can lead to abnormalities in the iris, lens, cornea, and overall eye development. PAX6 is also implicated in other conditions such as foveal hypoplasia 1, where the fovea, the central area of the retina responsible for sharp vision, fails to develop properly. Additionally, PAX6 has been associated with certain types of autism spectrum disorder, as it interacts with proteins involved in synaptic function and development. Further research is ongoing to better understand the function of PAX6 and its roles in various developmental processes. By studying this gene, scientists hope to gain insights into eye development and related disorders, potentially leading to improved diagnostics and therapeutic approaches.
Source	Rabbit
Specificity	The Pax-6 Antibody is capable of detecting the complete amount of Pax-6 present in the body. It is able to identify the endogenous levels of Pax-6, which makes it a reliable method of detecting the protein. The antibody is sensitive and specific and is therefore a useful tool in research studies involving Pax-6.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep;Horse;
Antigen	Pax-6
Application	The recommended dilutions for WB are between 1:1000 to 1:3000, whereas for IHC, it is suggested to use a dilution of 1:200. ELISA (peptide) is recommended to be used at a dilution range of 1:20000-1:40000. These dilutions have been determined based on the optimal conditions for the respective assays to provide accurate and reliable results. It is important to follow the recommended dilutions to ensure optimal performance of the assay.
Immunogen	A synthesized peptide derived from human Pax-6.
MW	47 kDa
Properties
Concentration	1mg/ml
purification	Through the utilization of SulfoLink™ Coupling Resin, the antiserum was effectively purified via peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality, store for one year at a temperature of -20 °C. Remember to prevent any occurrences of freezing and thawing cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.
Tissue specificity	Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form.
Posttranslational modification	Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation.
Celluar localization	Cytosol;Nucleus;
UniPort	P26367