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Rabbit Anti-GEMIN8 Polyclonal Antibody#abs138597

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Description

Catalog-specification	Delivery time	USD price
abs138597-100ug	1-2 Weeks	301.0
abs138597-50ug	1-2 Weeks	201.0

Overview
catalog	abs138597
Other names	FLJ20514, FLJ43072, and FAM51A1 are all names for a gem-associated protein that is located within the nucleus of cells. This protein, also known as gem8, plays an important role in the organization and function of this organelle. Through various studies, it has been shown that gem8 is involved in processes such as DNA damage response, gene expression, and cell division. Its precise functions are still being explored, but it is clear that this protein is an essential component of the nuclear landscape.
Source	Rabbit
Specificity	The presence of total GEMIN8 at the endogenous levels can be detected using the GEMIN8 Antibody. By rearranging the information in the original text, this content conveys the same meaning with a slightly different structure.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Sheep;Bovine;Horse;Pig;
Antigen	GEMIN8
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human GEMIN8.
MW	29kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	The recommended storage condition for this product is -20 °C for a duration of one year. It is crucial to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	This product contains Rabbit IgG dissolved in a buffer of phosphate buffered saline at pH 7.4, with 150mM NaCl, 0.02% sodium azide and 50% glycerol. It is recommended to store this product at a temperature of -20 °C, while it remains stable for up to 12 months from the date of receipt.
Target
Background	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Celluar localization	Cytosol;Nucleus;
UniPort	Q9NWZ8